The role of the polymorphic cytochrome P450 2D6 (CYP2D6) in the pharmacokinetics of
atomoxetine hydrochloride [(−)-N-methyl-γ-(2-methylphenoxy)benzenepropanamine …

The excitatory neurotransmitter glutamate has been implicated in both migraine and persistent
pain. The identification of the kainate receptor GLU K5 in dorsal root ganglia, the dorsal …

Phase I oxidative metabolism of nitrogen-containing drug molecules to their corresponding
N-oxides is a common occurrence. There are instances where liquid chromatography/…

A reversed-phase high-performance liquid chromatographic–electrochemical assay was
developed and validated for the quantification of olanzapine in human breast milk. The assay …

These studies were designed to characterize the disposition and metabolism of atomoxetine
hydrochloride [(−)-N-methyl-γ-(2-methylphenoxy)benzenepropanamine hydrochloride; …

Amino acids 5 and 7, two potent and selective competitive GluR5 KA receptor antagonists,
exhibited high GluR5 receptor affinity over other glutamate receptors. Their ester prodrugs 6 …

Amino diacid 3, a highly selective competitive GluR5 kainate receptor antagonist, exhibited
high GluR5 receptor affinity and selectivity over other glutamate receptors. Its diethyl ester …

Introduction: Glucuronidation by the uridine diphosphate glucuronosyltransferases (UGTs)
plays a pivotal role in the clearance mechanism of both xenobiotics and endobiotics. The …

Compound LY354740 [(+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid], an analog of
glutamic acid, is a selective group 2 metabotropic glutamate receptor agonist in clinical …

We have explored the decahydroisoquinoline scaffold, bearing a phenyl tetrazole, as GluK1
antagonists with potential as oral analgesics. We have established the optimal linker atom …