Despite oxycodone's (4, 5-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one)
history of clinical use and the attention it has received as a drug of abuse, few reports have …

After the ingestion of (-)-cotinine, the male human excreted (-)-cotinine, hydroxycotinine, and
γ-(3-pyridyl)-β-oxo-N-methylbutyramide. The two metabolites were isolated from urine and …

… ED 80 dose was given of a candidate δ-agonist. In vivo antagonist activity was determined by
giving an ED 80 dose of DPDPE icv 10 min before a sc ED … by givng an ED 80 dose of U69,…

The enantiomeric (-)-and (+)-2V-(methyl through decyl) normetazocines (5, 9a-dimethyl-2'-hydroxy-6,
7-benzomorphans) were synthesized and their in vitro and in vivo activities …

Following the smoking of tobacco or ingestion of nicotine the urine of human subjects contained
cotinine which was identified as the picrate and dipicrate. Chromatograms of the urines …

Many epidemiological studies have suggested a high correlation between the use of tobacco
and ethanol, the two most frequently abused psychoactive drugs. Recently, we reported …

RESULTS. The LD5O value for (-)-cotinine upon intraperitoneal administration was found to
be 930±35 mg/kg. The value for oral administration was 1604±452 mg/kg. Doses in excess …

Comparative analgesic studies revealed that dihydroetorphine was more potent than
etorphine in the tail-flick and hot-plate tests, respectively and nearly equipotent in the …

The biodisposition and metabolic fate of [ 3 H]sarin was investigated in mice after iv
administration of a sublethal dose (80 μg/kg). Within 1 min of administration, all tissues contained …

Early studies, in which the first resolution of racemic nicotine was accomplished showed 2
that 1-nicotine, the principal alkaloid of tobacco, was acutely less toxic than d-nicotine in …