… Swinyard: We are discussing epileptic patients refractory to diphenylhydantoin on the one
… Swinyard: There was no protection with doses as high as 3.6 g/day. It is possible that higher …

By means of the maximal electroshock seizure (MES) test, the subcutaneous
pentylenetetrazol (PTZ) seizure threshold test, and the Rotorod minimal neurotoxicity test, the …

Eight clinically employed antiepileptic drugs have been tested for anticonvulsant potency at
their time of peak effect in mice and rats by a battery of four assay procedures, as follows : …

DESPITE the high incidence of convulsive disorders and widespread use of shock therapy
in the major psychoses, relatively few investigations have dealt with the physiological …

In order to determine whether the recently described experimental "psychomotor" seizure (PsM.)
test in animals is a useful laboratory procedure for the screening and assay of …

The anticonvulsant potential of chemical substances can be identified with test procedures
that act at various biological levels, ranging from subcellular elements to the normal or …

The relative ability of phenytoin, ethosuximide and valproate to prevent minimal (clonic)
threshold, maximal (tonic extension of the hindlimbs) threshold and supramaximal (tonic …

… been published previously (Swinyard, 1972; Krall et al., 1978; Swinyard and Woodhead, …
Swinyard EA. Assay of antiepileptic drug activity in experimental animals: standard tests. In: …

The patterns of maximal seizures evoked in mice by the intravenous injection of 38 mgm./kgm.
Metrazol and by supramaximal electroshock have been compared. In addition, eight …

Malgré les besoins indiscutables en matiére de thérapies nouvelles, l'évaluation de la valeur
commerciale d'un nouveau medicament anti‐epileptique risque d'etre defavorisee aujourd'…