Parkinson’s disease psychosis (PDP) is a condition that may develop in up to 60 % of
Parkinson’s patients, and is a major reason for nursing home placement for those affected. There …

Currently available treatments for schizophrenia have limited efficacy and are generally poorly
tolerated. However, among these antipsychotic agents, clozapine stands apart in having …

Rationale Clozapine is a unique antipsychotic, with efficacy against positive symptoms in
treatment-resistant schizophrenic patients, and the ability to improve cognition and treat the …

We have used a cell-based functional assay to define the pharmacological profiles of a wide
range of central nervous system active compounds as agonists, competitive antagonists, …

The in vitro and in vivo pharmacological properties of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide
(2R,3R)-…

Drugs that antagonize D 2 -like receptors are effective antipsychotics, but the debilitating
movement disorder side effects associated with these drugs cannot be dissociated from …

Receptors have well-conserved regions that are recognized and activated by hormones and
neurotransmitters. Most drugs bind to these sites and mimic or block the action of the native …

Single 25 mg intravenous and 50 mg oral doses of trazodone were given to 43 healthy subjects,
divided into young men and women (aged 18 to 40 years) and elderly men and women (…

Nurr1 is a nuclear hormone receptor (NucHR) strongly implicated in the growth, maintenance,
and survival of dopaminergic neurons. Nurr1 may be unable to bind ligands directly, but it …

We have completed a systematic search of the intracellular loops of a muscarinic acetylcholine
receptor for domains that govern G-protein coupling. A unique feature of the second …