User profiles for E R Chilvers

Edwin Chilvers

Profesor of Respiratory Medicine, Cambridge University
Verified email at medschl.cam.ac.uk
Cited by 20175

[HTML][HTML] Neutrophil kinetics in health and disease

…, AM Condliffe, N Singh, AM Peters, ER Chilvers - Trends in …, 2010 - cell.com
Neutrophils play a key role in the elimination of pathogens. They are remarkably short-lived
with a circulating half life of 6–8h and hence are produced at a rate of 5×10 10 –10×10 10 …

Hypoxia-induced neutrophil survival is mediated by HIF-1α–dependent NF-κB activity

…, AS Cowburn, N Johnson, ER Chilvers - The Journal of …, 2005 - rupress.org
Chilvers; Hypoxia-induced neutrophil survival is mediated by HIF-1α–dependent NF-κB …
ER Chilvers is a recipient of noncommercial grants from AstraZeneca, UK and Boehringer …

Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo

…, AC MacKinnon, D Salter, C Choo, ER Chilvers… - Nature medicine, 1999 - nature.com
Resistance to chemotherapy is a principal problem in the treatment of small cell lung cancer
(SCLC). We show here that SCLC is surrounded by an extensive stroma of extracellular …

Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage

…, M Clatworthy, A Durandy, R Doffinger, ER Chilvers… - Science, 2013 - science.org
Genetic mutations cause primary immunodeficiencies (PIDs) that predispose to infections.
Here, we describe activated PI3K-δ syndrome (APDS), a PID associated with a dominant gain-…

Neutrophil priming: pathophysiological consequences and underlying mechanisms.

AM Condliffe, E Kitchen, ER Chilvers - Clinical science (London …, 1998 - europepmc.org
1. Neutrophil priming by agents such as tumour necrosis factor-alpha, granulocyte/macrophage
colony-stimulating factor and lipopolysaccharide causes a dramatic increase in the …

PtdIns (3) P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox

…, AB Holmes, PRJ Gaffney, J Coadwell, ER Chilvers… - Nature cell …, 2001 - nature.com
The production of reactive oxygen species (ROS) by neutrophils has a vital role in defence
against a range of infectious agents, and is driven by the assembly of a multi-protein complex …

[HTML][HTML] NF-κB activation is a critical regulator of human granulocyte apoptosis in vitro

C Ward, ER Chilvers, MF Lawson, JG Pryde… - Journal of Biological …, 1999 - ASBMB
During beneficial inflammation, potentially tissue-damaging granulocytes undergo apoptosis
before being cleared by phagocytes in a non-phlogistic manner. Here we show that the rate …

Efficacy and tolerability of anti‐immunoglobulin E therapy with omalizumab in patients with poorly controlled (moderate‐to‐severe) allergic asthma

JG Ayres, B Higgins, ER Chilvers, G Ayre, M Blogg… - Allergy, 2004 - Wiley Online Library
Background: Patients with poorly controlled asthma have greater morbidity and mortality.
This study evaluated the efficacy and tolerability of omalizumab in patients with poorly …

Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils

…, M Camps, C Rommel, SP Jackson, ER Chilvers… - Blood, 2005 - ashpublications.org
It is well established that preexposure of human neutrophils to proinflammatory cytokines
markedly augments the production of reactive oxygen species (ROS) to subsequent stimuli. …

Regulation of neutrophil apoptosis by tumor necrosis factor-α: requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro

…, I Dransfield, C Haslett, ER Chilvers - Blood, The Journal …, 1997 - ashpublications.org
Granulocyte apoptosis is an important mechanism underlying the removal of redundant
neutrophils from an inflammatory focus. The ability of many proinflammatory agents to impede …