In vitro models to predict blood-brain barrier permeability

EP Eddy, BE Maleef, TK Hart, PL Smith - Advanced drug delivery reviews, 1997 - Elsevier
The design and selection of centrally acting pharmaceuticals is a major challenge for drug
delivery to the brain. This review discusses the use of physicochemical parameters and cell …

[HTML][HTML] Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models

…, V Patwa, A Joshi, JA Foss, EP Eddy… - World Journal of …, 2018 - ncbi.nlm.nih.gov
AIM To investigate the effects of plecanatide and dolcanatide on maintenance of paracellular
permeability, integrity of tight junctions and on suppression of visceral hypersensitivity. …

Nonpeptide endothelin receptor antagonists. VI: Pharmacological characterization of SB 217242, a potent and highly bioavailable endothelin receptor antagonist.

…, A Lago, DW Hay, G Beck, KL Fong, EP Eddy… - … of Pharmacology and …, 1996 - ASPET
This study describes the pharmacological characterization of SB 217242, a highly potent
orally bioavailable nonpeptide antagonist of both endothelin type A (ETA) and endothelin type …

Exploitation of the intestinal oligopeptide transporter to enhance drug absorption

PL Smith, EP Eddy, CP Lee, G Wilson - Drug Delivery, 1993 - Taylor & Francis
Studies of the mechanisms involved in the transport of di- and tri-peptides by the intestinal
oligopeptide transporter suggest a process which involves proton-dependent uptake at the …

Mutagenicity, unscheduled DNA synthesis, and metabolism of 1-nitropyrene in the human hepatoma cell line HepG2

EP Eddy, PC Howard, GD McCoy, HS Rosenkranz - Cancer research, 1987 - AACR
The cell line HepG2 is derived from a well differentiated human hepatoblastoma, which
retains many of the morphological characteristics of liver parenchymal cells. These cells at …

In vitro permeability screening for identification of orally bioavailable endothelin receptor antagonists

H Ellens, EP Eddy, CP Lee, P Dougherty… - Advanced drug delivery …, 1997 - Elsevier
In vitro intestinal permeability screening identified a compound, SB 217242, in the indane
carboxylic acid series of endothelin receptor antagonists, with greatly improved permeability …

Pathways for the mutagenesis of 1-nitropyrene and dinitropyrenes in the human hepatoma cell line HepG2.

KJ Silvers, EP Eddy, EC McCoy… - Environmental …, 1994 - ehp.niehs.nih.gov
The mutagenicity, metabolism, DNA adduction and induction of unscheduled DNA synthesis
(UDS) of 1-nitropyrene and 1,8-dinitropyrene were investigated in the human hepatoma cell …

A comparison of the affinities of dipeptides and antibiotics for the di-/tripeptide transporter in Caco-2 cells

EP Eddy, C Wood, J Miller, G Wilson… - International journal of …, 1995 - Elsevier
The intestinal peptide transporter(s) is involved in the absorption of natural di-/tripeptides and
peptidomimetic drugs. Several key aspects of peptide transport such as number of peptide …

Evaluation of dermal toxicity and toxicokinetics of povidone‑iodine in Göttingen minipigs

EP Eddy, MS Shet, M Cataldo, D Grob… - Toxicology and Applied …, 2024 - Elsevier
Background Povidone‑iodine (PVP-I) is an effective and commonly used broad-spectrum
antiseptic; limited information exists around its long-term safety and impact on endocrine …

Nonpeptide endothelin receptor antagonists: IV. Identification of receptors in rabbit colonic mucosa and smooth muscle and correlation with physiological effects.

…, M Pullen, EH Ohlstein, G Beck, EP Eddy… - … of Pharmacology and …, 1995 - ASPET
Endothelin (ET) has been previously demonstrated to be a potent intestinal secretory stimuli
and to elicit intestinal smooth muscle contractions. In rat distal colon, the ETA receptor …