DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged …

CR Klaus, D Iwanowicz, D Johnston… - … of Pharmacology and …, 2014 - ASPET
EPZ-5676 [(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol],
a small-…

[HTML][HTML] Synergistic anti-tumor activity of EZH2 inhibitors and glucocorticoid receptor agonists in models of germinal center non-Hodgkin lymphomas

…, LD Johnston, CR Klaus, TJ Wigle, D Iwanowicz… - PloS one, 2014 - journals.plos.org
Patients with non-Hodgkin lymphoma (NHL) are treated today with a cocktail of drugs
referred to as CHOP (Cyclophosphamide, Hydroxyldaunorubicin, Oncovin, and Prednisone). …

Elongation Factor P is Dispensable in Escherichia coli and Pseudomonas aeruginosa

CJ Balibar, D Iwanowicz, CR Dean - Current microbiology, 2013 - Springer
Elongation factor P (EF-P) is a highly conserved ribosomal initiation factor responsible for
stimulating formation of the first peptide bond. Its essentiality has been debated and may differ …

[HTML][HTML] EZH2 inhibitor EPZ-6438 synergizes with anti-lymphoma therapies in preclinical models

…, N Warholic, CR Klaus, TJ Wigle, D Iwanowicz… - Blood, 2013 - Elsevier
Preclinical data have suggested that small molecule inhibitors for the histone methyltransferase
EZH2 represent potential new treatment modalities for Non-Hodgkin lymphomas (NHL) …

DOT1L inhibitor EPZ-5676 synergizes with cytarabine and azacitidine in preclinical models of MLL-rearranged leukemia

…, V Chopra, JA Keats, CT Campbell, D Iwanowicz… - Cancer Research, 2015 - AACR
EPZ-5676 is a small molecule inhibitor of the histone methyltransferase DOT1L currently in
clinical development and represents a first in class novel therapeutic agent for the treatment …

Engineering characteristics of compost used for erosion and sedimentation control

CL Ho, KC Wong, JP Seltzer - Geo-Frontiers 2011: Advances in …, 2011 - ascelibrary.org
The importance of minimizing detrimental impacts of erosion on construction sites has been
considered a pressing issue for decades. Conventional erosion control near wetlands …

[PDF][PDF] Are you ready fot some [club] football?

SGAEWTOB CLUB, FTO XAVIER - 2006 - core.ac.uk
… The Dorothy Day House invites you to attend a citywide health careˇ forum from 8:30 am -
2:00 p,m. on April 29. Registration for the event begins at 8:00 am The event will be held at the …

Evaluation of methodology in analyzing compost for erosion control

C Ho, K Wong, DA Reckhow - Transportation research …, 2008 - journals.sagepub.com
Preventing erosion has been considered an important, pressing issue for decades. The latest
techniques in conventional erosion control near wetlands use hay bales and silt fences. …

[PDF][PDF] Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome

…, AA Iwanowicz, LM Graves, EJ Iwanowicz… - Structure, 2023 - cell.com
The mitochondrial ClpP protease is responsible for mitochondrial protein quality control
through specific degradation of proteins involved in several metabolic processes. ClpP …

[PDF][PDF] The Campus Chronicle

B derides Romney - umass.edu
… In doubles action, junior Jafra Depontes and Price posted a 9-7 victory and freshman
Dorothy Iwanowicz and Edelstein won at No. 2 doubles. The team also lost to University of …