The pharmacology of ryanodine
DJ JENDEN, AS FAIRHURST - Pharmacological Reviews, 1969 - ASPET
Pharmacological potency of the order exhibited by ryanodine is usually associated with a
highly specific mechanism of action. The great variety of effects observed and the differences …
highly specific mechanism of action. The great variety of effects observed and the differences …
The source of choline for acetylcholine synthesis in brain
JJ Freeman, DJ Jenden - Life sciences, 1976 - Elsevier
More is known about the synthesis and metabolism of acetylcholine (ACh) than other choline
(Ch) containing compounds in the brain in spite of the fact that ACh represents only a small …
(Ch) containing compounds in the brain in spite of the fact that ACh represents only a small …
Choline deficiency: a cause of hepatic steatosis during parenteral nutrition that can be reversed with intravenous choline supplementation
…, DJ Jenden, M Roch, KM Rice, J Gornbein… - Hepatology, 1995 - journals.lww.com
Patients receiving long-term total parenteral nutrition (TPN) develop hepatic steatosis as a
complication. Our previous studies have shown this to be caused, at least in part, by choline …
complication. Our previous studies have shown this to be caused, at least in part, by choline …
In vivo 1H MRS choline: correlation with in vitro chemistry/histology
…, T Ernst, M Cornford, D Nikas, D McBride, DJ Jenden - Life sciences, 1996 - Elsevier
We correlated the in vivo 1 H Magnetic Resonance Spectroscopy (MRS) concentration of the
choline peak (CHO) with in vitrochemical measures of choline-containing compounds and …
choline peak (CHO) with in vitrochemical measures of choline-containing compounds and …
Choline deficiency causes reversible hepatic abnormalities in patients receiving parenteral nutrition: proof of a human choline requirement: a placebo‐controlled trial
…, M Sohel, M Dubin, DJ Jenden… - Journal of Parenteral …, 2001 - Wiley Online Library
Background: Previous studies have shown that plasma free choline concentrations are
significantly decreased in many long‐term home total parenteral nutrition (TPN) patients. …
significantly decreased in many long‐term home total parenteral nutrition (TPN) patients. …
In vivo proton magnetic resonance spectroscopy of the normal aging human brain
The effect of age on brain metabolite concentrations was evaluated using localized proton
magnetic resonance spectroscopy. This technique allows in vivo measurements of N-acetyl …
magnetic resonance spectroscopy. This technique allows in vivo measurements of N-acetyl …
Brain acetylcholine synthesis declines with senescence
GE Gibson, C Peterson, DJ Jenden - Science, 1981 - science.org
The synthesis of whole brain acetylcholine is reduced in two strains (C57BL and BALB/c) of
senescent mice. The incorporation of [U- 14 C]glucose into acetylcholine decreased in both …
senescent mice. The incorporation of [U- 14 C]glucose into acetylcholine decreased in both …
Cysteine String Proteins: a Potential Link Between Synaptic Vesicles and Presynaptic Ca2+ Channels
…, SM Parsons, GA Zampighi, DJ Jenden… - Science, 1994 - science.org
Presynaptic calcium channels are key regulators of neurotransmitter release. Oocyte
expression studies suggest that cysteine string proteins are essential subunits or modulators of …
expression studies suggest that cysteine string proteins are essential subunits or modulators of …
[HTML][HTML] Folate nutriture alters choline status of women and men fed low choline diets
RA Jacob, DJ Jenden, MA Allman-Farinelli… - The Journal of …, 1999 - Elsevier
Choline and folate share methylation pathways and, in studies of rats, were shown to be
metabolically inter-related. To determine whether choline status is related to folate intake in …
metabolically inter-related. To determine whether choline status is related to folate intake in …
Choline and phospholipid metabolism and the synthesis of acetylcholine in rat brain
RS Jope, DJ Jenden - Journal of neuroscience research, 1979 - Wiley Online Library
The metabolism of choline by rat brain, plasma, and liver was investigated using combined
gas chromatography mass spectrometry following microwave irradiation and treatment with …
gas chromatography mass spectrometry following microwave irradiation and treatment with …