Pharmacological potency of the order exhibited by ryanodine is usually associated with a
highly specific mechanism of action. The great variety of effects observed and the differences …

More is known about the synthesis and metabolism of acetylcholine (ACh) than other choline
(Ch) containing compounds in the brain in spite of the fact that ACh represents only a small …

Patients receiving long-term total parenteral nutrition (TPN) develop hepatic steatosis as a
complication. Our previous studies have shown this to be caused, at least in part, by choline …

We correlated the in vivo 1 H Magnetic Resonance Spectroscopy (MRS) concentration of the
choline peak (CHO) with in vitrochemical measures of choline-containing compounds and …

Background: Previous studies have shown that plasma free choline concentrations are
significantly decreased in many long‐term home total parenteral nutrition (TPN) patients. …

The effect of age on brain metabolite concentrations was evaluated using localized proton
magnetic resonance spectroscopy. This technique allows in vivo measurements of N-acetyl …

The synthesis of whole brain acetylcholine is reduced in two strains (C57BL and BALB/c) of
senescent mice. The incorporation of [U- 14 C]glucose into acetylcholine decreased in both …

Presynaptic calcium channels are key regulators of neurotransmitter release. Oocyte
expression studies suggest that cysteine string proteins are essential subunits or modulators of …

Choline and folate share methylation pathways and, in studies of rats, were shown to be
metabolically inter-related. To determine whether choline status is related to folate intake in …

The metabolism of choline by rat brain, plasma, and liver was investigated using combined
gas chromatography mass spectrometry following microwave irradiation and treatment with …