The multidrug resistance-associated protein (MRP) is the product of an ATP-binding cassette
transporter gene overexpressed in some tumor cells resistant to antineoplastic agents. We …

The membrane proteins mediating the ATP-dependent transport of lipophilic substances
conjugated to glutathione, glucuronate, or sulfate have been identified as members of the …

The multidrug resistance protein MRP1 functions as an ATP-dependent conjugate export
pump and confers multidrug resistance. We cloned MRP2 (symbol ABCC2), a MRP family …

We cloned and expressed a new organic anion transporting polypeptide (OATP), termed
human OATP2, (OATP-C, LST-1; symbol SLC21A6), involved in the uptake of various lipophilic …

Previous studies have identified the ATP-dependent export of glutathione conjugates as a
physiological function of the multidrug resistance protein (MRP). The involvement of MRP in …

ATP-dependent transport of glutathione and glucuronate conjugates from hepatocytes into
bile is mediated by a distinct member of the ATP-binding cassette superfamily. We have …

Based on sequence homology to the human organic anion transporting polypeptide 2 (OATP2;
SLC21A6), we cloned a new member of the SLC21A superfamily of solute carriers, …

Bilirubin, the end product of heme catabolism, is taken up from the blood circulation into the
liver. This work identifies a high-affinity transport protein mediating the uptake of bilirubin …

Several members of the multidrug resistance protein (MRP) family are expressed in the liver.
Adenosine triphosphate (ATP)-dependent transport of glutathione and glucuronoside …

Cellular export of cyclic nucleotides has been observed in various tissues and may represent
an elimination pathway for these signaling molecules, in addition to degradation by …