Thus far, clock genes in the heart have been described only in rodents, and alterations of
these genes have been associated with various myocardial malfunctions. In this study, we …

The presence of a nitrogen atom, charged at physiological pH, has frequently been considered
to be a hallmark of P-glycoprotein (PGP) inhibitors, although certain steroids, such as …

There has been an intensive debate whether dietary exposure to acrylamide could increase
the risk of human cancer since the first description of the presence of acrylamide in food in …

Amphetamine abuse is a major public health concern for which there is currently no
effective treatment. To develop effective treatments, the mechanisms by which amphetamine …

While classical cathinones, such as methcathinone, have been shown to be monoamine
releasing agents at human monoamine transporters, the subgroup of α-pyrrolidinophenones …

Cimicifuga racemosa (black cohosh) is commonly used in traditional medicines as treatment
for menopausal symptoms and as an antiinflammatory remedy. To clarify the mechanism of …

Propafenone analogs (PAs) were previously identified as potent inhibitors of P-glycoprotein
(Pgp)-mediated toxin efflux. For this as well as other classes of Pgp inhibitors, lipophilicity as …

The multispecific efflux transporter, P-glycoprotein, plays an important role in drug disposition.
Substrate translocation occurs along the interface of its transmembrane domains. The …

Cytosolic free calcium ions represent important second-messengers in platelets. Therefore,
quantitative measurement of intraplatelet calcium provides a popular and very sensitive tool …

Background and Purpose Amphetamines bind to the plasmalemmal transporters for the
monoamines dopamine ( DAT ), noradrenaline ( NET ) and 5‐HT ( SERT ); influx of …