Current evidence suggests that hypothalamic fatty acid metabolism may play a role in regulating
food intake; however, confirmation that it is a physiologically relevant regulatory system …

Glucagon-like peptide 1 (GLP-1) is a peptide hormone that is released from the gut in
response to nutrient ingestion and that has a range of metabolic effects, including enhancing …

Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …

We report the efficacy of a new peptide with agonism at the glucagon and GLP-1 receptors
that has potent, sustained satiation-inducing and lipolytic effects. Selective chemical …

BACKGROUND & AIMS: Surgical intervention produces sustainable weight loss and metabolic
improvement in obese individuals. Vertical sleeve gastrectomy (VSG) produces dramatic, …

We report the discovery of a new monomeric peptide that reduces body weight and diabetic
complications in rodent models of obesity by acting as an agonist at three key metabolically-…

We report the discovery and translational therapeutic efficacy of a peptide with potent, balanced
co-agonism at both of the receptors for the incretin hormones glucagon-like peptide-1 (…

Many homeostatic processes, including appetite and food intake, are controlled by neuroendocrine
circuits involving the CNS. The CNS also directly regulates adipocyte metabolism, as …

Disruptions of the melanocortin signaling system have been linked to obesity. We investigated
a possible role of the central nervous melanocortin system (CNS-Mcr) in the control of …

Obesity is associated with a state of chronic, low-grade inflammation characterized by
abnormal cytokine production and macrophage infiltration into adipose tissue, which may …