User profiles for Didier Cussac
CUSSAC Didier, PhDCussac Consulting Verified email at cussac-consulting.com Cited by 6760 |
The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical …
…, V Pasteau, JM Rivet, D Cussac - … of Pharmacology and …, 2003 - ASPET
Agomelatine (S20098) displayed pK i values of 6.4 and 6.2 at native (porcine) and cloned,
human (h)5-hydroxytryptamine (5-HT) 2C receptors, respectively. It also interacted with h5-HT …
human (h)5-hydroxytryptamine (5-HT) 2C receptors, respectively. It also interacted with h5-HT …
Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and …
MJ Millan, L Maiofiss, D Cussac, V Audinot… - … of Pharmacology and …, 2002 - ASPET
Because little comparative information is available concerning receptor profiles of antiparkinson
drugs, affinities of 14 agents were determined at diverse receptors implicated in the …
drugs, affinities of 14 agents were determined at diverse receptors implicated in the …
Agonist and antagonist actions of yohimbine as compared to fluparoxan at α2‐adrenergic receptors (AR) s, serotonin (5‐HT) 1A, 5‐HT1B, 5‐HT1D and dopamine D2 …
…, A Newman‐Tancredi, V Audinot, D Cussac… - Synapse, 2000 - Wiley Online Library
Herein, we evaluate the interaction of the α 2 ‐AR antagonist, yohimbine, as compared to
fluparoxan, at multiple monoaminergic receptors and examine their roles in the modulation of …
fluparoxan, at multiple monoaminergic receptors and examine their roles in the modulation of …
Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. III. Agonist and antagonist properties at serotonin, 5-HT1 and 5-HT2 …
A Newman-Tancredi, D Cussac, Y Quentric… - … of Pharmacology and …, 2002 - ASPET
Although certain antiparkinson agents interact with serotonin (5-HT) receptors, little
information is available concerning functional actions. Herein, we characterized efficacies of …
information is available concerning functional actions. Herein, we characterized efficacies of …
Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D2-like …
A Newman-Tancredi, D Cussac, V Audinot… - … of Pharmacology and …, 2002 - ASPET
The accompanying multivariate analysis of the binding profiles of antiparkinson agents
revealed contrasting patterns of affinities at diverse classes of monoaminergic receptor. Herein, …
revealed contrasting patterns of affinities at diverse classes of monoaminergic receptor. Herein, …
Triptolide is an inhibitor of RNA polymerase I and II–dependent transcription leading predominantly to down-regulation of short-lived mRNA
…, JQ Svejstrup, JP Annereau, D Cussac… - Molecular cancer …, 2009 - AACR
Triptolide, a natural product extracted from the Chinese plant Tripterygium wilfordii, possesses
antitumor properties. Despite numerous reports showing the proapoptotic capacity and …
antitumor properties. Despite numerous reports showing the proapoptotic capacity and …
[HTML][HTML] Ras, Rap, and Rac Small GTP-binding Proteins Are Targets for Clostridium sordellii Lethal Toxin Glucosylation (∗)
…, M Thelestam, P Chardin, D Cussac… - Journal of Biological …, 1996 - ASBMB
Lethal toxin (LT) from Clostridium sordellii is one of the high molecular mass clostridial
cytotoxins. On cultured cells, it causes a rounding of cell bodies and a disruption of actin stress …
cytotoxins. On cultured cells, it causes a rounding of cell bodies and a disruption of actin stress …
The GRB2 adaptor
P Chardin, D Cussac, S Maignan, A Ducruix - FEBS letters, 1995 - Wiley Online Library
Grb2 is an ‘adaptor’ protein made of one SH2 and two SH3 domains. The SH3 domains bind
to prolinerich motifs in the C‐terminal part of the ras exchange factor Sos. Binding of the …
to prolinerich motifs in the C‐terminal part of the ras exchange factor Sos. Binding of the …
The "selective" dopamine D1 receptor antagonist, SCH23390, is a potent and high efficacy agonist at cloned human serotonin2C receptors
…, A Newman-Tancredi, Y Quentric, D Cussac - …, 2001 - Springer
Rationale: The benzazepine and "selective" dopamine D 1 receptor antagonist, SCH23390 [(R)-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-benzazepine-7-ol],
shows …
shows …
S33084, a novel, potent, selective, and competitive antagonist at dopamine D3-receptors: I. Receptorial, electrophysiological and neurochemical profile compared …
…, A Newman-Tancredi, F Lejeune, D Cussac… - … of Pharmacology and …, 2000 - ASPET
The benzopyranopyrrole S33084 displayed pronounced affinity (pK i = 9.6) for cloned
human hD 3 -receptors, and >100-fold lower affinity for hD 2 and all other receptors (>30) …
human hD 3 -receptors, and >100-fold lower affinity for hD 2 and all other receptors (>30) …