Nox1 is involved in angiotensin II–mediated hypertension: a study in Nox1-deficient mice
K Matsuno, H Yamada, K Iwata, D Jin, M Katsuyama… - Circulation, 2005 - Am Heart Assoc
Background— Increased production of reactive oxygen species (ROSs) by angiotensin II (Ang
II) is involved in the initiation and progression of cardiovascular diseases. NADPH …
II) is involved in the initiation and progression of cardiovascular diseases. NADPH …
Bone marrow monocyte lineage cells adhere on injured endothelium in a monocyte chemoattractant protein-1–dependent manner and accelerate reendothelialization …
…, M Yoshida, Y Nishiwaki, Y Nozawa, D Jin… - Circulation …, 2003 - Am Heart Assoc
Peripheral blood (PB)-derived CD14 + monocytes were shown to transdifferentiate into
endothelial cell (EC) lineage cells and contribute to neovascularization. We investigated whether …
endothelial cell (EC) lineage cells and contribute to neovascularization. We investigated whether …
Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models
M Miyazaki, S Takai, D Jin, M Muramatsu - Pharmacology & therapeutics, 2006 - Elsevier
The discovery of a new angiotensin II (Ang II) pathway generated by mast cell chymase has
highlighted new biological functions for Ang II that is not related to the classic renin–…
highlighted new biological functions for Ang II that is not related to the classic renin–…
Angiotensin receptor-1 blocker inhibits atherosclerotic changes and endothelial disruption of the aortic valve in hypercholesterolemic rabbits
K Arishiro, M Hoshiga, N Negoro, D Jin, S Takai… - Journal of the American …, 2007 - jacc.org
Objectives : We sought to examine the effect of angiotensin receptor blocker (ARB) on the
formation of lesions in the aortic valves of hypercholesterolemic rabbits. Background : Recently…
formation of lesions in the aortic valves of hypercholesterolemic rabbits. Background : Recently…
NOX1/NADPH oxidase is involved in endotoxin-induced cardiomyocyte apoptosis
…, M Ibi, K Ikami, J Zhang, S Matoba, D Jin… - Free Radical Biology …, 2012 - Elsevier
The functional significance of NOX1/NADPH oxidase in the heart has not been explored due
to its low expression relative to other NOX homologs identified so far. We aimed to clarify …
to its low expression relative to other NOX homologs identified so far. We aimed to clarify …
A novel chymase inhibitor, 4-[1-{[bis-(4-methyl-phenyl)-methyl]-carbamoyl}-3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy]-benzoic acid (BCEAB), suppressed cardiac …
S Takai, D Jin, M Sakaguchi, S Katayama… - … of Pharmacology and …, 2003 - ASPET
Previously, we reported that levels of chymase activity and its mRNA in cardiac tissues were
significantly increased along with progression of cardiac fibrosis in cardiomyopathic …
significantly increased along with progression of cardiac fibrosis in cardiomyopathic …
Granulocyte Colony-Stimulating Factor–Mobilized Circulating c-Kit+/Flk-1+ Progenitor Cells Regenerate Endothelium and Inhibit Neointimal Hyperplasia After …
M Takamiya, M Okigaki, D Jin, S Takai… - … , and vascular biology, 2006 - Am Heart Assoc
Background— Granulocyte colony-stimulating factor (G-CSF) treatment was shown to inhibit
neointimal formation of balloon-injured vessels, whereas neither the identification of …
neointimal formation of balloon-injured vessels, whereas neither the identification of …
The relationship of tryptase-and chymase-positive mast cells to angiogenesis in stage I non-small cell lung cancer
T Ibaraki, M Muramatsu, S Takai, D Jin… - European journal of …, 2005 - academic.oup.com
Objective: There are two types of human mast cells, tryptase-positive mast cells (MC T ) and
tryptase- and chymase-positive mast cells (MC TC ). Although MC T have been reported to …
tryptase- and chymase-positive mast cells (MC TC ). Although MC T have been reported to …
Eplerenone inhibits atherosclerosis in nonhuman primates
S Takai, D Jin, M Muramatsu, K Kirimura, H Sakonjo… - …, 2005 - Am Heart Assoc
Aldosterone may be involved in the pathogenesis of atherosclerosis. We investigated the
effect of eplerenone, a selective mineralocorticoid receptor blocker, on atherosclerosis in …
effect of eplerenone, a selective mineralocorticoid receptor blocker, on atherosclerosis in …
Impact of chymase inhibitor on cardiac function and survival after myocardial infarction
D Jin, S Takai, M Yamada, M Sakaguchi… - Cardiovascular …, 2003 - academic.oup.com
Objectives: Recent studies have demonstrated that hamsters, like humans, possess both
angiotensin converting enzyme (ACE)- and chymase-dependent angiotensin (Ang) II-forming …
angiotensin converting enzyme (ACE)- and chymase-dependent angiotensin (Ang) II-forming …