User profiles for David J Figueroa

David Figueroa

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Cited by 11661

Characterization of the human cysteinyl leukotriene CysLT1 receptor

…, KM Metters, N Coulombe, M Abramovitz, DJ Figueroa… - Nature, 1999 - nature.com
The cysteinyl leukotrienes—leukotriene C 4 (LTC 4 ), leukotriene D 4 (LTD 4 ) and
leukotriene E 4 (LTE 4 )—are important mediators of human bronchial asthma 1 , 2 , 3 ,. …

[HTML][HTML] Characterization of the human cysteinyl leukotriene 2 receptor

CE Heise, BF O'Dowd, DJ Figueroa, N Sawyer… - Journal of Biological …, 2000 - ASBMB
The contractile and inflammatory actions of the cysteinyl leukotrienes (CysLTs), LTC 4 , LTD
4 , and LTE 4 , are thought to be mediated through at least two distinct but related CysLT G …

A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy

…, PW Wong, IM MacDonald, PA Sieving, DJ Figueroa… - Nature …, 2001 - nature.com
Stargardt-like macular dystrophy (STGD3, MIM 600110) and autosomal dominant macular
dystrophy (adMD) are inherited forms of macular degeneration characterized by decreased …

Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity

C Atkins, Q Liu, E Minthorn, SY Zhang, DJ Figueroa… - Cancer research, 2013 - AACR
The unfolded protein response (UPR) is a signal transduction pathway that coordinates cellular
adaptation to microenvironmental stresses that include hypoxia, nutrient deprivation, and …

N-((1S)-1-{[4-((2S)-2-{[(2, 4-dichlorophenyl) sulfonyl] amino}-3-hydroxypropanoyl)-1-piperazinyl] carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide …

KS Thorneloe, AC Sulpizio, Z Lin, DJ Figueroa… - … of Pharmacology and …, 2008 - ASPET
The transient receptor potential (TRP) vanilloid 4 (TRPV4) member of the TRP superfamily
has recently been implicated in numerous physiological processes. In this study, we describe …

A role for the melanocortin 4 receptor in sexual function

…, I Sebhat, AA Patchett, DJ Figueroa… - Proceedings of the …, 2002 - National Acad Sciences
By using a combination of genetic, pharmacological, and anatomical approaches, we show
that the melanocortin 4 receptor (MC4R), implicated in the control of food intake and energy …

Systemic activation of the transient receptor potential vanilloid subtype 4 channel causes endothelial failure and circulatory collapse: Part 2

…, K Thorneloe, ESR Lashinger, DJ Figueroa… - … of Pharmacology and …, 2008 - ASPET
The transient receptor potential (TRP) vanilloid subtype 4 (V4) is a nonselective cation
channel that exhibits polymodal activation and is expressed in the endothelium, where it …

[PDF][PDF] TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development

AP Vicari, DJ Figueroa, JA Hedrick, JS Foster… - Immunity, 1997 - cell.com
A novel CC chemokine was identified in the thymus of mouse and human and was
designated TECK (thymus-expressed chemokine). TECK has weak homology to other CC …

Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression

…, DJ Figueroa, CP Austin, MM Jiang, H Yu, J Ito… - Genomics, 2002 - Elsevier
To assess the contribution of potential central nervous system pathways implicated in the
control of appetite regulation and energy metabolism, it is essential to first identify appropriate …

Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes

DJ Figueroa, RM Breyer, SK DeFoe… - American journal of …, 2001 - atsjournals.org
The cysteinyl leukotrienes (CysLTs) are important mediators of human asthma. Pharmacologic
and clinical studies show that the CysLTs exert most of their bronchoconstrictive and …