LY320135 is a selective antagonist for the brain CB1 receptor, having greater than 70-fold
higher affinity for the CB1 than the peripheral CB2 receptor. The K i values for LY320135 at …

The azetidinone LY307174 (1) was identified as a screening lead for the vasopressin V1a
receptor (IC 50 45nM at the human V1a receptor) based on molecular similarity to …

Non peptide inhibitors of cathepsin D, an aspartyl protease that has been implicated in
many disease states including Alzheimer's disease, were prepared and evaluated. The most …

Three positional analogues (4-, 5-, and 7-) of benzothienylglycine and (7V-acetylindolinyl)-5-glycine
were prepared and coupled to 7-aminodeacetoxycephalosporanic acid (7-ADCA) to …

Computational chemistry made possible the prediction of the three-dimensional structures
of γ-lactam analogues of penems and carbapenems before the analogues were made. …

This study describes the integrated application of parallel synthesis and computational
chemistry to the design of potent nonpeptide antagonists for the neuropeptide Y-1 (NPY1) …

Volume 16, No. 3-4 (1984) OPPI BRIEF'S are laborious and thus rather expensive. A more
promising synthesis developed by Burckhal ter2 at ilizes a Friedel-Craf ts cyclizat ion, but …

The synthesis of [ 14 C]‐ and [ 2 H]‐labeled LY253351 (YM12617–1), a potent α 1 ‐receptor
antagonist, which is potentially useful in the treatment of benign prostatic hypertrophy (BPH) …

In recent years, there has been increased awareness 1n maintaining the quality of the
environment. This has led to the development and use of microbial agents as alternatives to …

… Since the dynamic variables in this network are the c^, we need to formulate a dynamic
equation for the Cjt that accomplishes this objective. We can achieve this by letting c^ follow the …