Modulation of anxiety through blockade of anandamide hydrolysis
The psychoactive constituent of cannabis, Δ 9 -tetrahydrocannabinol, produces in humans
subjective responses mediated by CB1 cannabinoid receptors, indicating that endogenous …
subjective responses mediated by CB1 cannabinoid receptors, indicating that endogenous …
An endocannabinoid mechanism for stress-induced analgesia
…, RL Suplita, NM Bolton, MH Neely, D Fegley… - Nature, 2005 - nature.com
Acute stress suppresses pain by activating brain pathways that engage opioid or non-opioid
mechanisms. Here we show that an opioid-independent form of this phenomenon, termed …
mechanisms. Here we show that an opioid-independent form of this phenomenon, termed …
Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3′-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and …
Fatty acid amide hydrolase (FAAH) is an intracellular serine enzyme that catalyzes the
hydrolysis of bioactive fatty acid ethanolamides such as anandamide and oleoylethanolamide (…
hydrolysis of bioactive fatty acid ethanolamides such as anandamide and oleoylethanolamide (…
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus
JK Makara, M Mor, D Fegley, SI Szabó, S Kathuria… - Nature …, 2005 - nature.com
The functions of 2-arachidonoylglycerol (2-AG), the most abundant endocannabinoid found
in the brain, remain largely unknown. Here we show that two previously unknown inhibitors …
in the brain, remain largely unknown. Here we show that two previously unknown inhibitors …
Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors
KM Jung, R Mangieri, C Stapleton, J Kim, D Fegley… - Molecular …, 2005 - ASPET
Activation of group I metabotropic glutamate (mGlu) receptors drives the endocannabinoid
system to cause both short- and long-term changes of synaptic strength in the striatum, …
system to cause both short- and long-term changes of synaptic strength in the striatum, …
Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia
RL Suplita II, T Gutierrez, D Fegley, D Piomelli… - …, 2006 - Elsevier
Recent work in our laboratories has demonstrated that an opioid-independent form of stress-induced
analgesia (SIA) is mediated by endogenous cannabinoids [Hohmann et al., 2005. …
analgesia (SIA) is mediated by endogenous cannabinoids [Hohmann et al., 2005. …
Challenges and strategies to facilitate formulation development of pediatric drug products: Safety qualification of excipients
…, S Salunke, K Thompson, G Baer, D Fegley… - International journal of …, 2018 - Elsevier
A public workshop entitled “Challenges and strategies to facilitate formulation development
of pediatric drug products” focused on current status and gaps as well as recommendations …
of pediatric drug products” focused on current status and gaps as well as recommendations …
Scientific and Regulatory Policy Committee Best Practices: documentation of sexual maturity by microscopic evaluation in nonclinical safety studies
…, M Bhaskaran, E de Rijk, D Fegley… - Toxicologic …, 2021 - journals.sagepub.com
The sexual maturity status of animals in nonclinical safety studies can have a significant impact
on the microscopic assessment of the reproductive system, the interpretation of potential …
on the microscopic assessment of the reproductive system, the interpretation of potential …
Erratum: Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus
JK Makara, M Mor, D Fegley, SI Szabo, S Kathuria… - Nature …, 2007 - nature.com
Our paper identified 6-methyl-2-p-tolylaminobenzo [d] oxazin-4-one (URB754; Specs) as a
monoacylglycerol lipase (MGL) inhibitor that enhances hippocampal depolarization-induced …
monoacylglycerol lipase (MGL) inhibitor that enhances hippocampal depolarization-induced …
Characterization of the fatty-acid amide hydrolase inhibitor URB597: Effects on anandamide and oleoylethanolamide deactivati
FAAH is the enzyme that catalyzes the hydrolysis of bioactive fatty acid ethanolamides such
as anandamide and oleoylethanolamide (OEA). Genetic deletion of the faah gene in mice …
as anandamide and oleoylethanolamide (OEA). Genetic deletion of the faah gene in mice …