The psychoactive constituent of cannabis, Δ 9 -tetrahydrocannabinol, produces in humans
subjective responses mediated by CB1 cannabinoid receptors, indicating that endogenous …

Acute stress suppresses pain by activating brain pathways that engage opioid or non-opioid
mechanisms. Here we show that an opioid-independent form of this phenomenon, termed …

Fatty acid amide hydrolase (FAAH) is an intracellular serine enzyme that catalyzes the
hydrolysis of bioactive fatty acid ethanolamides such as anandamide and oleoylethanolamide (…

The functions of 2-arachidonoylglycerol (2-AG), the most abundant endocannabinoid found
in the brain, remain largely unknown. Here we show that two previously unknown inhibitors …

Activation of group I metabotropic glutamate (mGlu) receptors drives the endocannabinoid
system to cause both short- and long-term changes of synaptic strength in the striatum, …

Recent work in our laboratories has demonstrated that an opioid-independent form of stress-induced
analgesia (SIA) is mediated by endogenous cannabinoids [Hohmann et al., 2005. …

A public workshop entitled “Challenges and strategies to facilitate formulation development
of pediatric drug products” focused on current status and gaps as well as recommendations …

The sexual maturity status of animals in nonclinical safety studies can have a significant impact
on the microscopic assessment of the reproductive system, the interpretation of potential …

Our paper identified 6-methyl-2-p-tolylaminobenzo [d] oxazin-4-one (URB754; Specs) as a
monoacylglycerol lipase (MGL) inhibitor that enhances hippocampal depolarization-induced …

FAAH is the enzyme that catalyzes the hydrolysis of bioactive fatty acid ethanolamides such
as anandamide and oleoylethanolamide (OEA). Genetic deletion of the faah gene in mice …