Opioids are potent drugs that are widely used to control wound or cancer pain. Increasing
evidence suggest that opioids mediate clinically relevant effects that go beyond their classical …

Inhibition of Janus-kinase 1/2 (JAK1/2) is a mainstay to treat myeloproliferative neoplasms (MPN).
Sporadic observations reported the co-incidence of B-cell non-Hodgkin lymphomas …

The opioid crisis of pain medication bears risks from addiction to cancer progression, but
little experimental evidence exists. Expression of δ-opioid receptors (DORs) correlates with …

Opioids promote tumor angiogenesis in mammary malignancies, but the underlying
signaling mechanism is largely unknown. The current study investigated the hypothesis that …

Mice lacking Cdk6 kinase activity suffer from mild anemia accompanied by elevated numbers
of Ter119+ cells in the bone marrow. The animals show hardly any alterations in erythroid …

STAT1 is an important regulator of NK cell maturation and cytotoxicity. Although the consequences
of Stat1-deficiency have been described in detail the underlying molecular functions …

Purpose Promising results have been described for antibodies binding vascular endothelial
growth factor (VEGF) in patients with corneal neovascularization. Whether veterinary …

Therapy of canine mammary tumours (CMTs) with classical antitumour drugs is problematic,
so better therapeutic options are needed. Palbociclib (PD‐0332991) is an innovative and …

Cyclin-dependent kinases (CDKs) are frequently deregulated in cancer and represent promising
drug targets. We provide evidence that CDK8 has a key role in B-ALL. Loss of CDK8 in …

Triple-negative breast cancer (TNBC) is an aggressive malignant disease that is responsible
for approximately 15% of breast cancers. The standard of care relies on surgery and …