Methods of evaluating and comparing the performance of diagnostic tests are of increasing
importance as new tests are developed and marketed. When a test is based on an observed …

Background Chemotherapy combinations that include an alkylating agent and a platinum
coordination complex have high response rates in women with advanced ovarian cancer. …

Background and Methods On behalf of the Gynecologic Oncology Group, we performed a
randomized trial of radiotherapy in combination with three concurrent chemotherapy regimens …

Purpose: In 1986, a protocol comparing primary radiation therapy (RT) plus hydrox yurea (HU)
to irradiation plus fluorouracil (5-FU) and cisplatin (CF) w as activated by the Gynecologic …

Background Intravenous platinum-based chemotherapy is the standard primary therapy for
advanced ovarian cancer. We conducted a phase 3 trial to compare the effects of …

Purpose Selective lymphadenectomy is widely accepted in the management of endometrial
cancer. Purported benefits are individualization of adjuvant therapy based on extent of …

Foreword This Journal feature begins with a case vignette highlighting a common clinical
problem. Evidence supporting various strategies is then presented, followed by a review of …

Hysterectomy is the most common gynecologic procedure performed in the United States,
with more than 600,000 procedures performed each year. Complications of hysterectomy vary …

Purpose We report the long-term survival and toxicity of a randomized phase III study
comparing cisplatin alone with cisplatin, flurouracil, and hydroxyurea versus hydroxyurea …

PURPOSE Cisplatin, mitolactol (dibromodulcitol), and ifosfamide have been the most active
single agents in squamous carcinoma of the cervix identified so far by the Gynecologic …