Flow-induced changes in vessel caliber tend to restore baseline wall shear stress (WSS) and
have been reported to be endothelium-dependent. To investigate the role of endothelium-…

Estrogen receptor alpha (ERα) has been recognized now for several decades as playing a
key role in reproduction and exerting functions in numerous nonreproductive tissues. In this …

Hypertension is one of the most frequent pathologies in the industrialized world. Although
recognized to be dependent on a combination of genetic and environmental factors, its …

Estrogen receptor alpha (ERα) activation functions AF-1 and AF-2 classically mediate gene
transcription in response to estradiol (E2). A fraction of ERα is targeted to plasma membrane …

Mechanotransduction plays a crucial role in vascular biology. One example of this is the
local regulation of vascular resistance via flow-mediated dilation (FMD). Impairment of this …

Objective— Cardiac damage and vascular dysfunction are major causes of morbidity and
mortality in hypertension. In the present study, we explored the beneficial therapeutic effect of …

In the developing chicken embryo yolk sac vasculature, the expression of arterial identity
genes requires arterial hemodynamic conditions. We hypothesize that arterial flow must …

Mycobacterium ulcerans, the etiological agent of Buruli ulcer, causes extensive skin lesions,
which despite their severity are not accompanied by pain. It was previously thought that this …

Microparticles (MPs) are small fragments generated from the plasma membrane after cell
stimulation. Among the candidate proteins harbored by MPs, we recently showed that sonic …

Resveratrol (RSV) has been shown to be involved in the regulation of energetic metabolism,
generating increasing interest in therapeutic use. SIRT1 has been described as the main …