Studies in nonhuman primates documented that appropriate stimulation of dopamine (DA)
D 1 receptors in the dorsolateral prefrontal cortex (DLPFC) is critical for working memory …

The human striatum is functionally organized into limbic, associative, and sensorimotor
subdivisions, which process information related to emotional, cognitive, and motor function. …

Context A long-standing version of the dopamine hypothesis of schizophrenia postulates
that hyperactivity of dopaminergic transmission at D 2 receptors in the limbic striatum is …

Dopamine transmission in the ventral striatum (VST), a structure which includes the nucleus
accumbens, ventral caudate, and ventral putamen, plays a critical role in the …

BACKGROUND: A decrease in dopamine type 2 receptors (D 2 ) and mesolimbic dopamine
transmission predisposes animals to consume alcohol. This study measured D 2 receptors …

Objective: Dopamine is an important mediator of the reinforcing effects of cocaine, and
alterations in dopamine function might be involved in cocaine dependence. The goals of the …

Striatal dopamine D 2 receptors have been implicated in the neurobiology of cocaine
addiction. Previous imaging studies showed reduced striatal D 2 receptor availability in chronic …

OBJECTIVE: The serotonin system is believed to play a role in modulating impulsivity and
violence. Previous imaging studies have implicated the anterior cingulate and orbitofrontal …

Serotonin 5-HT 1A receptors are implicated in the pathophysiology of neuropsychiatric
conditions. The goal of this study was to evaluate methods to derive 5-HT 1A receptor parameters …

OBJECTIVE: Ketamine is a noncompetitive antagonist at the glutamatergic N-methyl-d-aspartate
(NMDA) receptor that is used in human and animal medicine as an injectable anesthetic…