Cannabidiol as potential anticancer drug
…, M Solinas, V Cinquina, D Parolaro - British journal of clinical …, 2013 - Wiley Online Library
Over the past years, several lines of evidence support an antitumourigenic effect of cannabinoids
including Δ 9 ‐tetrahydrocannabinol (Δ 9 ‐THC), synthetic agonists, endocannabinoids …
including Δ 9 ‐tetrahydrocannabinol (Δ 9 ‐THC), synthetic agonists, endocannabinoids …
The endocannabinoid system and psychiatric disorders
D Parolaro, N Realini, D Vigano, C Guidali… - Experimental …, 2010 - Elsevier
The present review summarizes the latest information on the role and the pharmacological
modulation of the endocannabinoid system in mood disorders and its potential implication in …
modulation of the endocannabinoid system in mood disorders and its potential implication in …
Long lasting consequences of cannabis exposure in adolescence
T Rubino, D Parolaro - Molecular and cellular endocrinology, 2008 - Elsevier
… effects of cannabinoids, adult female rats were exposed to the same THC treatment paradigm
and no significant alterations in depressive-like behaviour were observed (Parolaro and …
and no significant alterations in depressive-like behaviour were observed (Parolaro and …
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
Although endocannabinoids constitute one of the first lines of defense against pain, the
anatomical locus and the precise receptor mechanisms underlying cannabinergic modulation of …
anatomical locus and the precise receptor mechanisms underlying cannabinergic modulation of …
Pharmacologic rescue of impaired cognitive flexibility, social deficits, increased aggression, and seizure susceptibility in oxytocin receptor null mice: a …
…, A Finardi, A Donzelli, L Pattini, T Rubino, D Parolaro… - Biological …, 2011 - Elsevier
… Although both genotypes learned to choose the baited arm at different rates during
acquisition (Figure 1D), the number of days needed to reach the criterion were not different. In …
acquisition (Figure 1D), the number of days needed to reach the criterion were not different. In …
[HTML][HTML] Chronic Δ9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical …
…, S Candeletti, M Sala, D Parolaro - …, 2008 - nature.com
Few and often contradictory reports exist on the long-term neurobiological consequences of
cannabinoid consumption in adolescents. The endocannabinoid system plays an important …
cannabinoid consumption in adolescents. The endocannabinoid system plays an important …
Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood
…, M Pinter, M Sala, R Bartesaghi, D Parolaro - …, 2009 - Wiley Online Library
… The NMDA receptor antagonist d-2-amino-5-phosphonopentanoate (d-AP5) impairs spatial
learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP …
learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP …
Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex
…, M Maccarrone, V Di Marzo, D Parolaro - Cerebral …, 2008 - academic.oup.com
In the present study we explored with a multidisciplinary approach, the role of anandamide (AEA)
in the modulation of anxiety behavior at the level of the prefrontal cortex (PFC). Low …
in the modulation of anxiety behavior at the level of the prefrontal cortex (PFC). Low …
Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines
…, A Colombo, MP Abbracchio, D Parolaro - … of Pharmacology and …, 2004 - ASPET
Recently, cannabinoids (CBs) have been shown to possess antitumor properties. Because
the psychoactivity of cannabinoid compounds limits their medicinal usage, we undertook the …
the psychoactivity of cannabinoid compounds limits their medicinal usage, we undertook the …
Oral anti-inflammatory activity of cannabidiol, a non-psychoactive constituent of cannabis, in acute carrageenan-induced inflammation in the rat paw
B Costa, M Colleoni, S Conti, D Parolaro… - Naunyn-Schmiedeberg's …, 2004 - Springer
Cannabidiol, the major non-psychoactive component of marijuana, has various pharmacological
actions of clinical interest. It is reportedly effective as an anti-inflammatory and anti-…
actions of clinical interest. It is reportedly effective as an anti-inflammatory and anti-…