TGF‐β signaling and the fibrotic response

A Leask, DJ Abraham - The FASEB Journal, 2004 - Wiley Online Library
… OLeask, A., Abraham, DJ TGF- signaling and the fibrotic response. FASEB J. 18, 816 –
827 (… Leask, A., Holmes, A., Black, CM, and Abraham, DJ (2003) CTGF gene regulation: …

All in the CCN family: essential matricellular signaling modulators emerge from the bunker

A Leask, DJ Abraham - Journal of cell science, 2006 - journals.biologists.com
Abraham; All in the CCN family: essential matricellular signaling modulators emerge from
the bunker. J Cell Sci 1 December 2006; 119 (23): 4803–4810. doi: https://doi.org/10.1242/jcs.…

Scleroderma: from cell and molecular mechanisms to disease models

DJ Abraham, J Varga - Trends in immunology, 2005 - cell.com
Scleroderma [also known as systemic sclerosis (SSc)] is a complex autoimmune disease
characterised by pathological remodelling of connective tissues. Although the earliest and most …

Quantitative evaluation of congo red binding to amyloid-like proteins with a beta-pleated sheet conformation.

…, JW Pettegrew, DJ Abraham - … of Histochemistry & …, 1989 - journals.sagepub.com
The binding of Congo red to several purified amyloid-like peptides having a beta-pleated
sheet conformation was quantitatively examined. Congo red binds preferentially to the beta-…

[HTML][HTML] CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling

A Holmes, DJ Abraham, S Sa, X Shiwen… - Journal of Biological …, 2001 - ASBMB
In normal adult fibroblasts, transforming growth factor-β (TGFβ) induces the expression of
connective tissue growth factor (CTGF). CTGF independently promotes fibroblast proliferation …

HINT: a new method of empirical hydrophobic field calculation for CoMFA

GE Kellogg, SF Semus, DJ Abraham - Journal of computer-aided …, 1991 - Springer
Abraham and Leo [11] proposed the use of hydrophobic atom constants that encode empirical
thermodynamic information to evaluate interactions (ie, docking) between small and large …

[HTML][HTML] Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis

…, DO Sillence, J Brinckmann, DJ Abraham… - Journal of Biological …, 2003 - ASBMB
The hallmark of fibrotic processes is an excessive accumulation of collagen. The deposited
collagen shows an increase in pyridinoline cross-links, which are derived from hydroxylated …

Clearing algorithms for barter exchange markets: Enabling nationwide kidney exchanges

DJ Abraham, A Blum, T Sandholm - … of the 8th ACM conference on …, 2007 - dl.acm.org
In barter-exchange markets, agents seek to swap their items with one another, in order to
improve their own utilities. These swaps consist of cycles of agents, with each agent receiving …

Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the …

…, CM Black, A Leask, DJ Abraham - Molecular biology of …, 2004 - Am Soc Cell Biol
The endothelins are a family of endothelium-derived peptides that possess a variety of functions,
including vasoconstriction. Endothelin-1 (ET-1) is up-regulated during tissue repair and …

[HTML][HTML] Connective tissue growth factor gene regulation: requirements for its induction by transforming growth factor-β2 in fibroblasts

A Leask, A Holmes, CM Black, DJ Abraham - Journal of Biological …, 2003 - ASBMB
In skin, the profibrotic protein connective tissue growth factor (CTGF) is not normally expressed.
However, when skin cells are exposed to transforming growth factor-β (TGF-β), CTGF is …