User profiles for D Grimes

D. Jay Grimes

Professor of Coastal Sciences
Verified email at usm.edu
Cited by 11076

Emerging marine diseases--climate links and anthropogenic factors

…, JM Burkholder, RR Colwell, PR Epstein, DJ Grimes… - Science, 1999 - science.org
Mass mortalities due to disease outbreaks have recently affected major taxa in the oceans.
For closely monitored groups like corals and marine mammals, reports of the frequency of …

Unsafe abortion: the preventable pandemic

DA Grimes, J Benson, S Singh, M Romero, B Ganatra… - The lancet, 2006 - thelancet.com
Ending the silent pandemic of unsafe abortion is an urgent public-health and human-rights
imperative. As with other more visible global-health issues, this scourge threatens women …

Allocation concealment in randomised trials: defending against deciphering

KF Schulz, DA Grimes - The Lancet, 2002 - thelancet.com
Proper randomisation rests on adequate allocation concealment. An allocation concealment
process keeps clinicians and participants unaware of upcoming assignments. Without it, …

Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2–positive …

…, M Tubiana-Hulin, S Chan, D Grimes… - Journal of clinical …, 2005 - ascopubs.org
Purpose This randomized, multicenter trial compared first-line trastuzumab plus docetaxel
versus docetaxel alone in patients with human epidermal growth factor receptor 2 (HER2) –…

Bias and causal associations in observational research

DA Grimes, KF Schulz - The lancet, 2002 - thelancet.com
Readers of medical literature need to consider two types of validity, internal and external.
Internal validity means that the study measured what it set out to; external validity is the ability …

Survival and viability of nonculturableEscherichia coli andVibrio cholerae in the estuarine and marine environment

…, N Roberts, FL Singleton, RW Attwell, DJ Grimes… - Microbial ecology, 1982 - Springer
Plating methods for estimating survival of indicator organisms, such asEscherichia coli, and
water-borne pathogens includingVibrio cholerae, have severe limitations when used to …

Viable but Non-Culturable Vibrio cholerae and Related Pathogens in the Environment: Implications for Release of Genetically Engineered Microorganisms

RR Colwell, PR Brayton, DJ Grimes, DB Roszak… - Bio/technology, 1985 - nature.com
In a series of microcosm and field studies, we have observed that over time V. cholerae and
related human pathogens enter a viable but non-culturable state. Direct viable counts by …

Blinding in randomised trials: hiding who got what

KF Schulz, DA Grimes - The Lancet, 2002 - thelancet.com
Blinding embodies a rich history spanning over two centuries. Most researchers worldwide
understand blinding terminology, but confusion lurks beyond a general comprehension. …

An overview of clinical research: the lay of the land

DA Grimes, KF Schulz - The lancet, 2002 - thelancet.com
Many clinicians report that they cannot read the medical literature critically. To address this
difficulty, we provide a primer of clinical research for clinicians and researchers alike. Clinical …

Generation of allocation sequences in randomised trials: chance, not choice

KF Schulz, DA Grimes - The Lancet, 2002 - thelancet.com
The randomised controlled trial sets the gold standard of clinical research. However,
randomisation persists as perhaps the least-understood aspect of a trial. Moreover, anything short …