Did you mean: D R Galanopoulos
Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors
…, H Cui, SE Dowdell, DE Gaitanopoulos… - Journal of medicinal …, 2007 - ACS Publications
Rho kinase (ROCK1) mediates vascular smooth muscle contraction and is a potential target
for the treatment of hypertension and related disorders. Indazole amide 3 was identified as a …
for the treatment of hypertension and related disorders. Indazole amide 3 was identified as a …
1-(carboxybenzyl) imidazole-5-acrylic acids: potent and selective angiotensin II receptor antagonists
…, RG Franz, DE Gaitanopoulos… - Journal of medicinal …, 1991 - ACS Publications
Conclusion In this communication we have described an efficient synthesis of an 126-labeled
photoaffinity probe of high affinity for human platelet TXA2/PGH2 receptors. The high …
photoaffinity probe of high affinity for human platelet TXA2/PGH2 receptors. The high …
Discovery of aminofurazan-azabenzimidazoles as inhibitors of Rho-kinase with high kinase selectivity and antihypertensive activity
…, RG Franz, DE Gaitanopoulos… - Journal of medicinal …, 2007 - ACS Publications
The discovery, proposed binding mode, and optimization of a novel class of Rho-kinase
inhibitors are presented. Appropriate substitution on the 6-position of the azabenzimidazole …
inhibitors are presented. Appropriate substitution on the 6-position of the azabenzimidazole …
Agonist and antagonist properties of benzazepine and thienopyridine derivatives at the D1 dopamine receptor
KM O'Boyle, DE Gaitanopoulos, M Brenner… - …, 1989 - Elsevier
Nine structurally related 1-phenyl-1H-3-benzazepine derivatives and two thienopyridines
were tested for agonist and antagonist properties at the adenylate cyclase-coupled D 1 …
were tested for agonist and antagonist properties at the adenylate cyclase-coupled D 1 …
Potent nonpeptide angiotensin II receptor antagonists. 2. 1-(Carboxybenzyl) imidazole-5-acrylic acids
…, RG Franz, DE Gaitanopoulos… - Journal of medicinal …, 1993 - ACS Publications
… via the malonate intermediate 86 (Scheme VI), and the olefin regioisomer 65 was isolated
from a mixture of products resulting from base hydrolysis of an acrylonitrile intermediate as de…
from a mixture of products resulting from base hydrolysis of an acrylonitrile intermediate as de…
Imidazole-5-acrylic acids: potent nonpeptide angiotensin II receptor antagonists designed using a novel peptide pharmacophore model
…, RG Franz, DE Gaitanopoulos… - Journal of medicinal …, 1992 - ACS Publications
A series of novel nonpeptide angiotensin II receptor antagonists containing a substituted (Elacrylic
acid has been developed. The overlay of 1, an imidazole-5-acetic acid found in the …
acid has been developed. The overlay of 1, an imidazole-5-acetic acid found in the …
Synthesis and evaluation of non-catechol D-1 and D-2 dopamine receptor agonists: benzimidazol-2-one, benzoxazol-2-one, and the highly potent: benzothiazol-2 …
J Weinstock, DE Gaitanopoulos… - Journal of medicinal …, 1987 - ACS Publications
… Previous publications from our laboratory have de-scribed the potent presynaptic D-2 (DA2)
7 dopamine re-ceptor agonist activity of 4-[2-(di-n-propylamino) ethyl]-7-hydroxy-2 (3H)-…
7 dopamine re-ceptor agonist activity of 4-[2-(di-n-propylamino) ethyl]-7-hydroxy-2 (3H)-…
2‐Azabicyclo [2.2. 1] heptane‐3‐carboxylic acid‐A bicyclic proline
DE Gaitanopoulos, J Weinstock - Journal of heterocyclic …, 1985 - Wiley Online Library
Diels‐Alder reaction of cyclopentadiene and methyl N‐carbobenzyloxy‐2‐iminoacetate
generated in situ from methyl 2‐chloro‐N‐carbobenzyloxyglycinate by triethylamine gave the N‐…
generated in situ from methyl 2‐chloro‐N‐carbobenzyloxyglycinate by triethylamine gave the N‐…
The discovery of tertiary-amine LXR agonists with potent cholesterol efflux activity in macrophages
…, C Ma, HJ Oh, D Lee, DE Gaitanopoulos… - Bioorganic & medicinal …, 2009 - Elsevier
The liver X receptors (LXR) play a key role in cholesterol homeostasis and lipid metabolism.
SAR studies around tertiary-amine lead molecule 2, an LXR full agonist, revealed that steric …
SAR studies around tertiary-amine lead molecule 2, an LXR full agonist, revealed that steric …
Identification of fenoldopam prodrugs with prolonged renal vasodilator activity.
…, K Karpinski, B Mico, DE Gaitanopoulos… - … of Pharmacology and …, 1990 - ASPET
Fenoldopam (SK&F 82526) is a short-acting selective dopamine-1 agonist in clinical trials for
the treatment of hypertension, congestive heart failure and renal failure. In the present study…
the treatment of hypertension, congestive heart failure and renal failure. In the present study…
Did you mean to search for: D R Galanopoulos