Did you mean: D R Galanopoulos

Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors

…, H Cui, SE Dowdell, DE Gaitanopoulos… - Journal of medicinal …, 2007 - ACS Publications
Rho kinase (ROCK1) mediates vascular smooth muscle contraction and is a potential target
for the treatment of hypertension and related disorders. Indazole amide 3 was identified as a …

1-(carboxybenzyl) imidazole-5-acrylic acids: potent and selective angiotensin II receptor antagonists

…, RG Franz, DE Gaitanopoulos… - Journal of medicinal …, 1991 - ACS Publications
Conclusion In this communication we have described an efficient synthesis of an 126-labeled
photoaffinity probe of high affinity for human platelet TXA2/PGH2 receptors. The high …

Discovery of aminofurazan-azabenzimidazoles as inhibitors of Rho-kinase with high kinase selectivity and antihypertensive activity

…, RG Franz, DE Gaitanopoulos… - Journal of medicinal …, 2007 - ACS Publications
The discovery, proposed binding mode, and optimization of a novel class of Rho-kinase
inhibitors are presented. Appropriate substitution on the 6-position of the azabenzimidazole …

Agonist and antagonist properties of benzazepine and thienopyridine derivatives at the D1 dopamine receptor

KM O'Boyle, DE Gaitanopoulos, M Brenner… - …, 1989 - Elsevier
Nine structurally related 1-phenyl-1H-3-benzazepine derivatives and two thienopyridines
were tested for agonist and antagonist properties at the adenylate cyclase-coupled D 1 …

Potent nonpeptide angiotensin II receptor antagonists. 2. 1-(Carboxybenzyl) imidazole-5-acrylic acids

…, RG Franz, DE Gaitanopoulos… - Journal of medicinal …, 1993 - ACS Publications
… via the malonate intermediate 86 (Scheme VI), and the olefin regioisomer 65 was isolated
from a mixture of products resulting from base hydrolysis of an acrylonitrile intermediate as de

Imidazole-5-acrylic acids: potent nonpeptide angiotensin II receptor antagonists designed using a novel peptide pharmacophore model

…, RG Franz, DE Gaitanopoulos… - Journal of medicinal …, 1992 - ACS Publications
A series of novel nonpeptide angiotensin II receptor antagonists containing a substituted (Elacrylic
acid has been developed. The overlay of 1, an imidazole-5-acetic acid found in the …

Synthesis and evaluation of non-catechol D-1 and D-2 dopamine receptor agonists: benzimidazol-2-one, benzoxazol-2-one, and the highly potent: benzothiazol-2 …

J Weinstock, DE Gaitanopoulos… - Journal of medicinal …, 1987 - ACS Publications
… Previous publications from our laboratory have de-scribed the potent presynaptic D-2 (DA2)
7 dopamine re-ceptor agonist activity of 4-[2-(di-n-propylamino) ethyl]-7-hydroxy-2 (3H)-…

2‐Azabicyclo [2.2. 1] heptane‐3‐carboxylic acid‐A bicyclic proline

DE Gaitanopoulos, J Weinstock - Journal of heterocyclic …, 1985 - Wiley Online Library
Diels‐Alder reaction of cyclopentadiene and methyl N‐carbobenzyloxy‐2‐iminoacetate
generated in situ from methyl 2‐chloro‐N‐carbobenzyloxyglycinate by triethylamine gave the N‐…

The discovery of tertiary-amine LXR agonists with potent cholesterol efflux activity in macrophages

…, C Ma, HJ Oh, D Lee, DE Gaitanopoulos… - Bioorganic & medicinal …, 2009 - Elsevier
The liver X receptors (LXR) play a key role in cholesterol homeostasis and lipid metabolism.
SAR studies around tertiary-amine lead molecule 2, an LXR full agonist, revealed that steric …

Identification of fenoldopam prodrugs with prolonged renal vasodilator activity.

…, K Karpinski, B Mico, DE Gaitanopoulos… - … of Pharmacology and …, 1990 - ASPET
Fenoldopam (SK&F 82526) is a short-acting selective dopamine-1 agonist in clinical trials for
the treatment of hypertension, congestive heart failure and renal failure. In the present study…
Did you mean to search for: D R Galanopoulos