A major cause of alcohol toxicity is the production of reactive oxygen species generated
during ethanol metabolism. The aim of this study was to compare the effect of binge drinking‐…

Some clinical studies have shown that anxiety disorders are often associated with drug
dependence, although it remains unclear whether these disorders are primary or secondary to …

Sensation seeking is frequently observed among drug addicts. This behaviour has been
modelled in non-primate animals as novelty seeking. We previously determined that novelty …

Rationale Sensation/novelty seeking is frequently observed in drug abusers. Rats with high
locomotor activity in response to inescapable novelty may be more prone to drug addiction. …

Rationale Drug addiction is defined as a recurring cycle of intoxication, abstinence and
relapse. The behavioural trait of novelty seeking is frequently observed in alcohol abusers. …

… After having shown that the d~rect DA agomsts tested were … the D-2 dopamine receptors
(bromocriptine) or the D-1 and D-… acting preferentially on D-2 receptors, and by sulpiride, a D-2 …

We compared the ability of various dopamine (DA) uptake inhibitors to displace the in vivo
striatal [ 3 H]GBR 12783 (1-[2(diphenylmethoxy) ethyl)-4-(3-phenyl-1[ 3 H]-2-propenyl)-…

THE rewarding and locomotor effects of the specific dopamine uptake inhibitor GBR12783 (2.5–20
mg kg− 1, ip) were compared with those of cocaine. For both drugs, all doses …

… Expérimentale, Faculté de Médecine et de Pharmacie de Rouen, 22, Bld Gambetta
76000 Rouen, France; Fax: 33-02-35-14-86-03; E-mail: dominique.duterte-boucher@univ-rouen.fr. …

Rats were treated once daily for 15 consecutive days with either cocaine or the specific
dopamine uptake inhibitor 1-[2-(diphenylmethoxy) ethyl]-4-(3-phenyl-2-(propenyl)-piperazine (…