The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model
…, S Becker, E Callegari, C Chen, X Chen… - Drug Metabolism and …, 2005 - ASPET
Thirty-two structurally diverse drugs used for the treatment of various conditions of the central
nervous system (CNS), along with two active metabolites, and eight non-CNS drugs were …
nervous system (CNS), along with two active metabolites, and eight non-CNS drugs were …
Development of a computational approach to predict blood-brain barrier permeability
X Liu, M Tu, RS Kelly, C Chen, BJ Smith - Drug metabolism and disposition, 2004 - ASPET
The objectives of this study were to generate a data set of blood-brain barrier (BBB) permeability
values for drug-like compounds and to develop a computational model to predict BBB …
values for drug-like compounds and to develop a computational model to predict BBB …
P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists
C Chen, E Hanson, JW Watson, JS Lee - Drug Metabolism and Disposition, 2003 - ASPET
The present study evaluates the impact of P-glycoprotein (P-gp) on plasma-brain disposition
and transepithelial transport of sedating versus nonsedating H1-antagonists using multidrug…
and transepithelial transport of sedating versus nonsedating H1-antagonists using multidrug…
Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1
C Chen, RJ Mireles, SD Campbell, J Lin, JB Mills… - Drug Metabolism and …, 2005 - ASPET
The present study examined the interaction of four 3-hydroxy-3-methylglutaryl coenzyme A
reductase inhibitors (atorvastatin, lovastatin, and simvastatin in acid and lactone forms, and …
reductase inhibitors (atorvastatin, lovastatin, and simvastatin in acid and lactone forms, and …
Use of a physiologically based pharmacokinetic model to study the time to reach brain equilibrium: an experimental analysis of the role of blood-brain barrier …
…, C Chen, E Callegari, SL Becker, X Chen… - … of Pharmacology and …, 2005 - ASPET
This study was designed 1) to examine the effects of blood-brain barrier (BBB) permeability [quantified
as permeability-surface area product (PS)], unbound fraction in plasma (f u,…
as permeability-surface area product (PS)], unbound fraction in plasma (f u,…
Progress in brain penetration evaluation in drug discovery and development
X Liu, C Chen, BJ Smith - Journal of Pharmacology and Experimental …, 2008 - ASPET
This review discusses strategies to optimize brain penetration from the perspective of drug
discovery and development. Brain penetration kinetics can be described by the extent and …
discovery and development. Brain penetration kinetics can be described by the extent and …
Evaluation of cerebrospinal fluid concentration and plasma free concentration as a surrogate measurement for brain free concentration
…, C Chen, E Callegari, SL Becker, X Chen… - Drug metabolism and …, 2006 - ASPET
This study was designed to evaluate the use of cerebrospinal fluid (CSF) drug concentration
and plasma unbound concentration (C u,plasma ) to predict brain unbound concentration (…
and plasma unbound concentration (C u,plasma ) to predict brain unbound concentration (…
Enhanced soil washing of phenanthrene by a plant-derived natural biosurfactant, Sapindus saponin
W Zhou, X Wang, C Chen, L Zhu - Colloids and Surfaces A …, 2013 - Elsevier
Biosurfactants have great advantages for using in environmental remediation as their
environmental friendly nature. In this study, a plant-derived natural biosurfactant of Sapindus …
environmental friendly nature. In this study, a plant-derived natural biosurfactant of Sapindus …
[HTML][HTML] Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as potential predictors of prognosis in acute ischemic stroke
C Chen, L Gu, L Chen, W Hu, X Feng, F Qiu… - Frontiers in …, 2021 - frontiersin.org
Objective: Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have
been emerging as the novel inflammatory biomarkers for determining the prognosis of …
been emerging as the novel inflammatory biomarkers for determining the prognosis of …
Study on the inhibitory effect of tannins and flavonoids against the 1, 1-diphenyl-2-picrylhydrazyl radical
T Yokozawa, CP Chen, E Dong, T Tanaka… - Biochemical …, 1998 - Elsevier
Fifty-one tannins and forty-one flavonoids isolated from Oriental medicinal herbs were
evaluated for their antioxidant ability with a 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-…
evaluated for their antioxidant ability with a 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-…