Glycan optimization of a human monoclonal antibody in the aquatic plant Lemna minor
…, A Black, D Passmore, C Moldovan-Loomis… - Nature …, 2006 - nature.com
N-glycosylation is critical to the function of monoclonal antibodies (mAbs) and distinguishes
various systems used for their production. We expressed human mAbs in the small aquatic …
various systems used for their production. We expressed human mAbs in the small aquatic …
Pharmacologic characterization of ALD1910, a potent humanized monoclonal antibody against the pituitary adenylate cyclase-activating peptide
CM Loomis, B Dutzar, EW Ojala, L Hendrix… - … of Pharmacology and …, 2019 - ASPET
Migraine is a debilitating disease that affects almost 15% of the population worldwide and is
the first cause of disability in people under 50 years of age, yet its etiology and …
the first cause of disability in people under 50 years of age, yet its etiology and …
PACAP induces light aversion in mice by an inheritable mechanism independent of CGRP
…, AS Reis, LP Sowers, CM Loomis… - Journal of …, 2021 - Soc Neuroscience
The neuropeptides CGRP (calcitonin gene-related peptide) and PACAP (pituitary adenylate
cyclase-activating polypeptide) have emerged as mediators of migraine, yet the potential …
cyclase-activating polypeptide) have emerged as mediators of migraine, yet the potential …
Repetitive stress in mice causes migraine-like behaviors and calcitonin gene-related peptide-dependent hyperalgesic priming to a migraine trigger
…, M Motina, L Quigley, C Burgos-Vega, CM Loomis… - Pain, 2020 - journals.lww.com
Migraine is one of the most disabling disorders worldwide but the underlying mechanisms
are poorly understood. Stress is consistently reported as a common trigger of migraine attacks…
are poorly understood. Stress is consistently reported as a common trigger of migraine attacks…
Peripherally administered calcitonin gene–related peptide induces spontaneous pain in mice: Implications for migraine
…, CJ Brown, BN Mason, MC Moldovan-Loomis… - Pain, 2018 - journals.lww.com
Migraine is the third most common disease in the world (behind dental caries and tension-type
headache) with an estimated global prevalence of 15%, yet its etiology remains poorly …
headache) with an estimated global prevalence of 15%, yet its etiology remains poorly …
[HTML][HTML] Repetitive stress in mice causes migraine-like behaviors and CGRP-dependent hyperalgesic priming to a migraine trigger
…, M Motina, L Quigley, C Burgos-Vega, CM Loomis… - Pain, 2020 - ncbi.nlm.nih.gov
Migraine is the second-most disabling disease worldwide [27], characterized by unilateral
throbbing pain, cutaneous allodynia, often accompanied by nausea and sensitivity to light and …
throbbing pain, cutaneous allodynia, often accompanied by nausea and sensitivity to light and …
A nonfucosylated human antibody to CD19 with potent B-cell depletive activity for therapy of B-cell malignancies
…, H Huang, A Pham, MC Moldovan-Loomis… - Cancer immunology …, 2010 - Springer
A human anti-CD19 antibody was expressed in fucosyltransferase-deficient CHO cells to
generate nonfucosylated MDX-1342. Binding of MDX-1342 to human CD19-expressing cells …
generate nonfucosylated MDX-1342. Binding of MDX-1342 to human CD19-expressing cells …
In vitro and In vivo Characterization of MDX-1401 for Therapy of Malignant Lymphoma
PM Cardarelli, MC Moldovan-Loomis, B Preston… - Clinical Cancer …, 2009 - AACR
Purpose: This study was undertaken to evaluate the effects of MDX-1401, a nonfucosylated
fully human monoclonal antibody that binds to human CD30, and to determine whether it …
fully human monoclonal antibody that binds to human CD30, and to determine whether it …
AI-based antibody discovery platform identifies novel, diverse and pharmacologically active therapeutic antibodies against multiple SARS-CoV-2 strains
C Moldovan Loomis, T Lahlali, D Van Citters… - bioRxiv, 2023 - biorxiv.org
A critical aspect of a successful pandemic response is expedient antibody discovery,
manufacturing and deployment of effective lifesaving treatments to patients around the world. …
manufacturing and deployment of effective lifesaving treatments to patients around the world. …
AI-based antibody discovery platform identifies novel, diverse and pharmacologically active therapeutic antibodies against multiple SARS-CoV-2 strains (preprint)
CM Loomis, T Lahlali, D Van Citters, M Sprague… - 2023 - pesquisa.bvsalud.org
A critical aspect of a successful pandemic response is expedient antibody discovery,
manufacturing and deployment of effective lifesaving treatments to patients around the world. …
manufacturing and deployment of effective lifesaving treatments to patients around the world. …