By using a combination of genetic, pharmacological, and anatomical approaches, we show
that the melanocortin 4 receptor (MC4R), implicated in the control of food intake and energy …

Dipeptidyl peptidase IV (DP-IV) is a cell surface serine dipeptidase that is involved in the
regulation of the incretin hormones, glucagon-like peptide (GLP-1) and glucose-dependent …

Purpose: The plant-derived compound curcumin has shown promising abilities as a cancer
chemoprevention and chemotherapy agent in vitro and in vivo but exhibits poor …

Synthetic and natural peptides that act as nonselective melanocortin receptor agonists have
been found to be anorexigenic and to stimulate erectile activity. We report the design and …

Background This study examined the safety, pharmacokinetics, and efficacy of transarterial
chemoembolization of hepatocellular carcinoma (HCC) using a newly developed size of a …

Background Pancreatic ductal adenocarcinoma (PDA) is frequently driven by oncogenic
KRAS(KRAS*) mutations. We developed a mouse model of KRAS*-induced PDA and, based on …

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the
loss of dopaminergic (DAergic) neurons in the substantia nigra and the gradual depletion of …

Introduction The objective of this study was to evaluate the efficacy of intravenous (iv) injection
of liposomally encapsulated dexamethasone phosphate (DxM-P) in comparison to free …

Peptide and protein drugs have evolved in recent years into mainstream therapeutics,
representing a significant portion of the pharmaceutical market. Peptides and proteins exhibit …

This study aimed to identify candidate new diagnosis and prognosis markers and medicinal
targets of prostate cancer (PCa), using state of the art proteomics. A total of 20 prostate …