User profiles for Colton L. Linnertz

Colton L Linnertz

Bioinformatician - University of North Carolina at Chapel Hill
Verified email at med.unc.edu
Cited by 993

Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice

…, CJ Reames, RK Meade, BK Hampton, CL Linnertz… - Elife, 2022 - elifesciences.org
The outcome of an encounter with Mycobacterium tuberculosis (Mtb) depends on the
pathogen’s ability to adapt to the variable immune pressures exerted by the host. Understanding …

Whole genome sequencing and progress toward full inbreeding of the mouse collaborative cross population

…, A Kashfeen, KE Kirchoff, CL Linnertz… - G3: Genes …, 2019 - academic.oup.com
Two key features of recombinant inbred panels are well-characterized genomes and
reproducibility. Here we report on the sequenced genomes of six additional Collaborative Cross (…

Zhx2 is a candidate gene underlying oxymorphone metabolite brain concentration associated with state-dependent oxycodone reward

…, AA Shah, KD Sena, AL Wong, CL Linnertz… - … of Pharmacology and …, 2022 - ASPET
Understanding the pharmacogenomics of opioid metabolism and behavior is vital to therapeutic
success, as mutations can dramatically alter therapeutic efficacy and addiction liability. …

[HTML][HTML] Forward genetic screen of homeostatic antibody levels in the Collaborative Cross identifies MBD1 as a novel regulator of B cell homeostasis

…, KS Plante, AC Whitmore, CL Linnertz… - PLoS …, 2022 - journals.plos.org
Variation in immune homeostasis, the state in which the immune system is maintained in the
absence of stimulation, is highly variable across populations. This variation is attributed to …

[HTML][HTML] Genetic loci regulate Sarbecovirus pathogenesis: A comparison across mice and humans

…, S Chamberlin, TA Bell, DT Scobey, CL Linnertz… - Virus Research, 2024 - Elsevier
Coronavirus (CoV) cause considerable morbidity and mortality in humans and other mammals,
as evidenced by the emergence of Severe Acute Respiratory CoV (SARS-CoV) in 2003, …

[HTML][HTML] Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice

…, FR Moreira, MN Batista, MT Ferris, CL Linnertz… - Hepatology, 2024 - journals.lww.com
Background & Aims: Human genetic variation is thought to guide the outcome of HCV infection,
but model systems within which to dissect these host genetic mechanisms are limited. …

Genetic regulation of homeostatic immune architecture in the lungs of collaborative cross mice

BK Hampton, KL Jensen, AC Whitmore, CL Linnertz… - bioRxiv, 2021 - biorxiv.org
Variation in immune homeostasis, immune system stability, in organ systems such as the
lungs is likely to shape the host response to infection at these exposed tissues. We evaluated …

[HTML][HTML] A mutation in Themis contributes to peanut-induced oral anaphylaxis in CC027 mice

…, MCC Cisneros, BK Hampton, P Hock, CL Linnertz… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Background: The development of peanut allergy is due to a combination of genetic and
environmental factors, although specific genes have proven difficult to identify. Previously, we …

Sarbecovirus disease susceptibility is conserved across viral and host models

…, TA Bell, P Hock, MR Zweigart, CL Linnertz… - bioRxiv, 2023 - biorxiv.org
Coronaviruses have caused three severe epidemics since the start of the 21st century: SARS,
MERS and COVID-19. The severity of the ongoing COVID-19 pandemic and increasing …

Sarbecovirus disease susceptibility is conserved across viral and host models (preprint)

…, TA Bell, P Hock, MR Zweigart, CL Linnertz… - 2023 - pesquisa.bvsalud.org
Coronaviruses have caused three severe epidemics since the start of the 21st century SARS,
MERS and COVID-19. The severity of the ongoing COVID-19 pandemic and increasing …