User profiles for Colton L. Linnertz
Colton L LinnertzBioinformatician - University of North Carolina at Chapel Hill Verified email at med.unc.edu Cited by 993 |
Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice
…, CJ Reames, RK Meade, BK Hampton, CL Linnertz… - Elife, 2022 - elifesciences.org
The outcome of an encounter with Mycobacterium tuberculosis (Mtb) depends on the
pathogen’s ability to adapt to the variable immune pressures exerted by the host. Understanding …
pathogen’s ability to adapt to the variable immune pressures exerted by the host. Understanding …
Whole genome sequencing and progress toward full inbreeding of the mouse collaborative cross population
Two key features of recombinant inbred panels are well-characterized genomes and
reproducibility. Here we report on the sequenced genomes of six additional Collaborative Cross (…
reproducibility. Here we report on the sequenced genomes of six additional Collaborative Cross (…
Zhx2 is a candidate gene underlying oxymorphone metabolite brain concentration associated with state-dependent oxycodone reward
…, AA Shah, KD Sena, AL Wong, CL Linnertz… - … of Pharmacology and …, 2022 - ASPET
Understanding the pharmacogenomics of opioid metabolism and behavior is vital to therapeutic
success, as mutations can dramatically alter therapeutic efficacy and addiction liability. …
success, as mutations can dramatically alter therapeutic efficacy and addiction liability. …
[HTML][HTML] Forward genetic screen of homeostatic antibody levels in the Collaborative Cross identifies MBD1 as a novel regulator of B cell homeostasis
…, KS Plante, AC Whitmore, CL Linnertz… - PLoS …, 2022 - journals.plos.org
Variation in immune homeostasis, the state in which the immune system is maintained in the
absence of stimulation, is highly variable across populations. This variation is attributed to …
absence of stimulation, is highly variable across populations. This variation is attributed to …
[HTML][HTML] Genetic loci regulate Sarbecovirus pathogenesis: A comparison across mice and humans
…, S Chamberlin, TA Bell, DT Scobey, CL Linnertz… - Virus Research, 2024 - Elsevier
Coronavirus (CoV) cause considerable morbidity and mortality in humans and other mammals,
as evidenced by the emergence of Severe Acute Respiratory CoV (SARS-CoV) in 2003, …
as evidenced by the emergence of Severe Acute Respiratory CoV (SARS-CoV) in 2003, …
[HTML][HTML] Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice
Background & Aims: Human genetic variation is thought to guide the outcome of HCV infection,
but model systems within which to dissect these host genetic mechanisms are limited. …
but model systems within which to dissect these host genetic mechanisms are limited. …
Genetic regulation of homeostatic immune architecture in the lungs of collaborative cross mice
BK Hampton, KL Jensen, AC Whitmore, CL Linnertz… - bioRxiv, 2021 - biorxiv.org
Variation in immune homeostasis, immune system stability, in organ systems such as the
lungs is likely to shape the host response to infection at these exposed tissues. We evaluated …
lungs is likely to shape the host response to infection at these exposed tissues. We evaluated …
[HTML][HTML] A mutation in Themis contributes to peanut-induced oral anaphylaxis in CC027 mice
…, MCC Cisneros, BK Hampton, P Hock, CL Linnertz… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Background: The development of peanut allergy is due to a combination of genetic and
environmental factors, although specific genes have proven difficult to identify. Previously, we …
environmental factors, although specific genes have proven difficult to identify. Previously, we …
Sarbecovirus disease susceptibility is conserved across viral and host models
Coronaviruses have caused three severe epidemics since the start of the 21st century: SARS,
MERS and COVID-19. The severity of the ongoing COVID-19 pandemic and increasing …
MERS and COVID-19. The severity of the ongoing COVID-19 pandemic and increasing …
Sarbecovirus disease susceptibility is conserved across viral and host models (preprint)
Coronaviruses have caused three severe epidemics since the start of the 21st century SARS,
MERS and COVID-19. The severity of the ongoing COVID-19 pandemic and increasing …
MERS and COVID-19. The severity of the ongoing COVID-19 pandemic and increasing …