The present review focuses on the structural modifications responsible for the transformation
of an antibacterial into an anticancer agent. Indeed, a distinctive feature of drugs based on …

We have developed novel G-quadruplex (G-4) ligand/alkylating hybrid structures, tethering
the naphthalene diimide moiety to quaternary ammonium salts of Mannich bases, as quinone…

G-quadruplex structures can be formed at the single-stranded overhang of telomeric DNA,
and ligands able to stabilize this structure have recently been identified as potential …

The synthesis, physico-chemical properties and biological effects of a new class of naphthalene
diimides (NDIs) capable of reversibly binding telomeric DNA and alkylate it through an …

The catalytic steps through which DNA topoisomerases produce their biological effects and
the interference of drug molecules with the enzyme–DNA cleavage complex have been …

Aptamers are short DNA- or RNA-based oligonucleotides selected from large combinatorial
pools of sequences for their capacity to efficiently recognize targets ranging from small …

… Claudia Sissi - Dipartimento di Scienze Chimiche and CNR-ITM, Università di Padova,
Padova, Italy, Dipartimento di Scienze Farmaceutiche, Università di Padova, Padova, Italy …

Background G-rich sequences undergo unique structural equilibria to form G-quadruplexes (G4)
both in vitro and in cell systems. Several pathologies emerged to be directly related to …

The physiological and pharmacological role of nucleic acids structures folded into the non
canonical G-quadruplex conformation have recently emerged. Their activities are targeted at …

Platinum-complexes represent some of the most successful groups of clinically used
anticancer drugs. Their mechanism of action relies on the formation of stable DNA adducts …