Ferroptosis is a form of nonapoptotic cell death for which key regulators remain unknown. We
sought a common mediator for the lethality of 12 ferroptosis-inducing small molecules. We …

Aberrant activation of the mammalian target of rapamycin complex 1 (mTORC1) is a common
molecular event in a variety of pathological settings, including genetic tumor syndromes, …

Emerging technologies allow the high-throughput profiling of metabolic status from a blood
specimen (metabolomics). We investigated whether metabolite profiles could predict the …

Leukotrienes (LTs) and prostaglandins (PGs) amplify acute inflammation, whereas lipoxins (LXs)
have unique anti-inflammatory actions. Temporal analyses of these eicosanoids in …

Inflammatory bowel diseases, which include Crohn’s disease and ulcerative colitis, affect
several million individuals worldwide. Crohn’s disease and ulcerative colitis are complex …

The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …

The inflammatory bowel diseases (IBDs), which include Crohn’s disease (CD) and ulcerative
colitis (UC), are multifactorial chronic conditions of the gastrointestinal tract. While IBD has …

Aspirin therapy inhibits prostaglandin biosynthesis without directly acting on lipoxygenases,
yet via acetylation of cyclooxygenase 2 (COX-2) it leads to bioactive lipoxins (LXs) epimeric …

Metabolic reprogramming has been proposed to be a hallmark of cancer, yet a systematic
characterization of the metabolic pathways active in transformed cells is currently lacking. …

SIRT6 is a member of a highly conserved family of NAD + -dependent deacetylases with
various roles in metabolism, stress resistance, and life span. SIRT6-deficient mice develop …