Metformin is among the most widely prescribed drugs for the treatment of type 2 diabetes.
Organic cation transporter 1 (OCT1) plays a role in the hepatic uptake of metformin, but its role …

Premature birth is a significant cause of infant and child morbidity and mortality. In the United
States, the premature birth rate, which had steadily increased during the 1990s and early …

The NIH Pharmacogenetics Research Network (PGRN) is a collaborative group of investigators
with a wide range of research interests, but all attempting to correlate drug response with …

Objective The goal of this study was to determine the effect of a genetic variant in the organic
cation transporter 2 (OCT2), OCT2-808G/T, which results in an amino acid change, A270S, …

Interindividual variation in response to metformin, first‐line therapy for type 2 diabetes, is
substantial. Given that transporters are determinants of metformin pharmacokinetics, we …

Methotrexate (MTX) is used in patients with malignant and autoimmune diseases. This drug
is primarily excreted unchanged in the urine, and its net excretion occurs via active secretory …

▪ Abstract Organic cation transporters are critical in drug absorption, targeting, and disposition.
It has become increasingly clear that multiple mechanisms are involved in organic cation …

Review of abdominal CT scans for evaluation of blunt abdominal trauma yielded 35 cases
of pneumothorax, 10 of which had not been diagnosed before CT by clinical examination or …

Pre-Induction of Anesthesia in Pediatric Patients with Nasal... : Survey of Anesthesiology Pre-Induction
of Anesthesia in Pediatric Patients with Nasally Administered Sufentanil : Survey of …

The human organic anion transporter, OAT3 (SLC22A8), plays a critical role in renal drug
elimination, by mediating the entry of a wide variety of organic anions, including a number of …