Nicotine and other nicotinic agents are thought to regulate mood in human subjects and have
antidepressant-like properties in animal models. Recent studies have demonstrated that …

Introduction: Nicotinic acetylcholine receptors (nAChRs), pentameric ligand-gated cation
channels, are potential targets for the development of therapeutics for a variety of disease states…

Aim: Comparison of tapentadol prolonged release (PR) with other oral WHO-III PR opioid
analgesics (morphine, oxycodone ± naloxone, hydromorphone) in routine medical care of …

Partial agonist therapies for the treatment of nicotine addiction and dependence depend on
both agonistic and antagonistic effects of the ligands, and side effects associated with other …

In this study thirty-three novel indole derivatives were designed and synthesized based on
the structure of deformylflustrabromine B (1), a metabolite isolated from the marine bryozoan …

3,7-Diazabicyclo[3.3.1]nonane (bispidine) based nicotinic acetylcholine receptor (nAChR)
ligands have been synthesized and evaluated for nAChRs interaction. Diverse spacer motifs …

3,7-Diazabicyclo[3.3.1]nonane is a naturally occurring scaffold interacting with nicotinic
acetylcholine receptors (nAChRs). When one nitrogen of the 3,7-diazabicyclo[3.3.1]nonane …

… and Konrad Eibl. Konrad Eibl co-wrote and discussed the manuscript. Adrian Usler co-wrote
and discussed the manuscript in his research project under the supervision of Konrad Eibl. …

Background This prospective, open-label trial was conducted to fulfil a post-approval
commitment made to the competent authorities to extend the indication of the strong opioid …

Im Rahmen des Citizen Science Projekts „Augmented Reality im Klassenzimmer: Klimawandel
(be-) greifbar machen “wurden Schüler* innen der Sekundarstufe II an die Thematik des …