Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases
C Sridar, TC Goosen, UM Kent, JA Williams… - Drug metabolism and …, 2004 - ASPET
Silybin, a major constituent of the milk thistle, is used to treat several liver disorders. Silybin
inactivated purified, recombinant cytochromes P450 (P450) 3A4 and 2C9 in a mechanism-…
inactivated purified, recombinant cytochromes P450 (P450) 3A4 and 2C9 in a mechanism-…
The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6
Members of the cytochrome P450 (P450) family of drug-metabolizing enzymes are present
in the human brain, and they may have important roles in the oxidation of endogenous …
in the human brain, and they may have important roles in the oxidation of endogenous …
Polymorphic variants of cytochrome P450 2B6 (CYP2B6. 4–CYP2B6. 9) exhibit altered rates of metabolism for bupropion and efavirenz: a charge-reversal mutation in …
In this study, metabolism of bupropion, efavirenz, and 7-ethoxy-4-trifluoromethylcoumarin (7-EFC)
by CYP2B6 wild type (CYP2B6.1) and six polymorphic variants (CYP2B6.4 to CYP2B6.…
by CYP2B6 wild type (CYP2B6.1) and six polymorphic variants (CYP2B6.4 to CYP2B6.…
Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6
C Sridar, NT Snider, PF Hollenberg - Drug Metabolism and Disposition, 2011 - ASPET
Anandamide is an arachidonic acid-derived endogenous cannabinoid that regulates
normal physiological functions and pathophysiological responses within the central nervous …
normal physiological functions and pathophysiological responses within the central nervous …
Effect of tamoxifen on the enzymatic activity of human cytochrome CYP2B6
C Sridar, UM Kent, LM Notley, EMJ Gillam… - … of Pharmacology and …, 2002 - ASPET
Tamoxifen is primarily used in the treatment of breast cancer. It has been approved as a
chemopreventive agent for individuals at high risk for this disease. Tamoxifen is metabolized to …
chemopreventive agent for individuals at high risk for this disease. Tamoxifen is metabolized to …
Bioactivation of the cancer chemopreventive agent tamoxifen to quinone methides by cytochrome P4502B6 and identification of the modified residue on the …
C Sridar, J D'Agostino, PF Hollenberg - Drug Metabolism and Disposition, 2012 - ASPET
The nonsteroidal antiestrogen tamoxifen was introduced as a treatment for breast cancer 3
decades ago. It has also been approved as a chemopreventive agent and is prescribed to …
decades ago. It has also been approved as a chemopreventive agent and is prescribed to …
The inactivation of human CYP2E1 by phenethyl isothiocyanate, a naturally occurring chemopreventive agent, and its oxidative bioactivation
Y Yoshigae, C Sridar, UM Kent, PF Hollenberg - Drug Metabolism and …, 2013 - ASPET
Phenethylisothiocyanate (PEITC), a naturally occurring isothiocyanate and potent cancer
chemopreventive agent, works by multiple mechanisms, including the inhibition of cytochrome …
chemopreventive agent, works by multiple mechanisms, including the inhibition of cytochrome …
The naturally occurring cytochrome P450 (P450) 2B6 K262R mutant of P450 2B6 exhibits alterations in substrate metabolism and inactivation
NN Bumpus, C Sridar, UM Kent… - Drug metabolism and …, 2005 - ASPET
The polymorphic human cytochrome P450 (P450) 2B6 is primarily responsible for the
metabolism of several clinically relevant drugs including bupropion, cyclophosphamide, propofol, …
metabolism of several clinically relevant drugs including bupropion, cyclophosphamide, propofol, …
Inhibition of bupropion metabolism by selegiline: mechanism-based inactivation of human CYP2B6 and characterization of glutathione and peptide adducts
C Sridar, C Kenaan, PF Hollenberg - Drug Metabolism and Disposition, 2012 - ASPET
Selegiline, the R-enantiomer of deprenyl, is used in the treatment of Parkinson's disease.
Bupropion, an antidepressant, often used to treat patients in conjunction with selegiline, is …
Bupropion, an antidepressant, often used to treat patients in conjunction with selegiline, is …
Differential inhibition of cytochromes P450 3A4 and 3A5 by the newly synthesized coumarin derivatives 7-coumarin propargyl ether and 7-(4-trifluoromethyl) coumarin …
C Sridar, UM Kent, K Noon, A McCall, B Alworth… - Drug metabolism and …, 2008 - ASPET
The abilities of 7-coumarin propargyl ether (CPE) and 7-(4-trifluoromethyl)coumarin
propargyl ether (TFCPE) to act as mechanism-based inactivators of P450 3A4 and 3A5 in the …
propargyl ether (TFCPE) to act as mechanism-based inactivators of P450 3A4 and 3A5 in the …