The 2005 World Health Organization reevaluation of human and mammalian toxic equivalency factors for dioxins and dioxin-like compounds
In June 2005, a World Health Organization (WHO)-International Programme on Chemical
Safety expert meeting was held in Geneva during which the toxic equivalency factors (TEFs) …
Safety expert meeting was held in Geneva during which the toxic equivalency factors (TEFs) …
Modulation of oestrogen receptor signalling by association with the activated dioxin receptor
…, H Kitagawa, Y Yamamoto, K Nohara, C Tohyama… - Nature, 2003 - nature.com
Environmental contaminants affect a wide variety of biological events in many species. Dioxins
are typical environmental contaminants that exert adverse oestrogen-related effects 1 . …
are typical environmental contaminants that exert adverse oestrogen-related effects 1 . …
Schema-dependent gene activation and memory encoding in neocortex
…, M Kakeyama, Y Kajii, H Okuno, C Tohyama… - Science, 2011 - science.org
When new learning occurs against the background of established prior knowledge, relevant
new information can be assimilated into a schema and thereby expand the knowledge base…
new information can be assimilated into a schema and thereby expand the knowledge base…
Metallothionein in radiation exposure: its induction and protective role
L Cai, M Satoh, C Tohyama, MG Cherian - Toxicology, 1999 - Elsevier
Since its discovery about 40 years ago, there has been a wide interdisciplinary research
interest in metallothionein (MT) on its physiological and toxicological aspects. Functionally, MT …
interest in metallothionein (MT) on its physiological and toxicological aspects. Functionally, MT …
Polybrominated Dibenzo-p-Dioxins, Dibenzofurans, and Biphenyls: Inclusion in the Toxicity Equivalency Factor Concept for Dioxin-Like Compounds
In 2011, a joint World Health Organization (WHO) and United Nations Environment
Programme (UNEP) expert consultation took place, during which the possible inclusion of …
Programme (UNEP) expert consultation took place, during which the possible inclusion of …
Bisphenol-A affects spermatogenesis in the adult rat even at a low dose
…, Y Aoki, J Yonemoto, C Tohyama - … of occupational health, 2001 - jstage.jst.go.jp
Materials and Methods Animal and treatment Male Sprague-Dawley rats (11 weeks old) were
purchased from CLEA Japan, Inc.(Tokyo, Japan) and housed in stainless wire cages until …
purchased from CLEA Japan, Inc.(Tokyo, Japan) and housed in stainless wire cages until …
Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse
…, Y Aoki, N Nishimura, C Tohyama… - Proceedings of the …, 2003 - National Acad Sciences
There are large inter- and intraspecies differences in susceptibility to dioxin-induced toxicities.
A critical question in risk assessment of dioxin and related compounds is whether humans …
A critical question in risk assessment of dioxin and related compounds is whether humans …
Exposure of Mouse Preimplantation Embryos to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Alters the Methylation Status of Imprinted Genes H19 and Igf2
…, R Ishimura, JS Suzuki, C Tohyama - Biology of …, 2004 - academic.oup.com
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an extremely toxic, persistent environmental
contaminant that disrupts normal development in laboratory animals. In our earlier study, we …
contaminant that disrupts normal development in laboratory animals. In our earlier study, we …
Dickkopf 1 (DKK1) regulates skin pigmentation and thickness by affecting Wnt/β‐catenin signaling in keratinocytes
…, K Yasumoto, T Hara, C Tohyama… - The FASEB …, 2008 - Wiley Online Library
The epidermis (containing primarily ker‐atinocytes and melanocytes) overlies the dermis (containing
primarily fibroblasts) of human skin. We previously reported that dickkopf 1 (DKK1) …
primarily fibroblasts) of human skin. We previously reported that dickkopf 1 (DKK1) …
Perspectives on cadmium toxicity research
…, H Koyama, T Kaji, H Kito, C Tohyama - The Tohoku journal of …, 2002 - jstage.jst.go.jp
Since there are a plethora of studies on cadmium toxicity and poisoning in laboratory
animals and humans, we have limited this review to studies that are relevant to human health …
animals and humans, we have limited this review to studies that are relevant to human health …