The clinical KRAS (G12C) inhibitor AMG 510 drives anti-tumour immunity
…, K Cooke, D Bagal, K Gaida, T Holt, CG Knutson… - Nature, 2019 - nature.com
KRAS is the most frequently mutated oncogene in cancer and encodes a key signalling
protein in tumours 1 , 2 . The KRAS(G12C) mutant has a cysteine residue that has been …
protein in tumours 1 , 2 . The KRAS(G12C) mutant has a cysteine residue that has been …
[HTML][HTML] Engineered human blood–brain barrier microfluidic model for vascular permeability analyses
…, S Zhang, O Morozova, D Hickman, CG Knutson… - Nature protocols, 2022 - nature.com
The blood–brain barrier (BBB) greatly restricts the entry of biological and engineered therapeutic
molecules into the brain. Due to challenges in translating results from animal models to …
molecules into the brain. Due to challenges in translating results from animal models to …
Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer
A Mangerich, CG Knutson, NM Parry… - Proceedings of the …, 2012 - National Acad Sciences
Helicobacter hepaticus-infected Rag2 -/- mice emulate many aspects of human inflammatory
bowel disease, including the development of colitis and colon cancer. To elucidate …
bowel disease, including the development of colitis and colon cancer. To elucidate …
[HTML][HTML] The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants
…, AD Gruber, J Bushe, O Kershaw, CG Knutson… - Nature …, 2022 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
with potential resistance to existing drugs emphasizes the need for new therapeutic …
with potential resistance to existing drugs emphasizes the need for new therapeutic …
Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease
CG Knutson, A Mangerich, Y Zeng… - Proceedings of the …, 2013 - National Acad Sciences
Inflammatory bowel disease (IBD) arises from inappropriate activation of the mucosal
immune system resulting in a state of chronic inflammation with causal links to colon cancer. …
immune system resulting in a state of chronic inflammation with causal links to colon cancer. …
An on-chip model of protein paracellular and transcellular permeability in the microcirculation
…, MR Gillrie, R Li, O Morozova, D Hickman, CG Knutson… - Biomaterials, 2019 - Elsevier
Recent therapeutic success of large-molecule biologics has led to intense interest in assays
to measure with precision their transport across the vascular endothelium and into the target …
to measure with precision their transport across the vascular endothelium and into the target …
Studies on the chemical reactivity of diclofenac acyl glucuronide with glutathione: identification of diclofenac-S-acyl-glutathione in rat bile
MP Grillo, CG Knutson, PE Sanders, DJ Waldon… - Drug metabolism and …, 2003 - ASPET
Diclofenac, a nonsteroidal anti-inflammatory drug, is metabolized to a reactive acyl glucuronide
that has been proposed to mediate toxic adverse drug reactions associated with its use. …
that has been proposed to mediate toxic adverse drug reactions associated with its use. …
Application of transmural flow across in vitro microvasculature enables direct sampling of interstitial therapeutic molecule distribution
In vitro prediction of physiologically relevant transport of therapeutic molecules across the
microcirculation represents an intriguing opportunity to predict efficacy in human populations. …
microcirculation represents an intriguing opportunity to predict efficacy in human populations. …
Site-specific and redox-controlled S-nitrosation of thioredoxin
KT Barglow, CG Knutson, JS Wishnok… - Proceedings of the …, 2011 - National Acad Sciences
Protein S-nitrosation on cysteine residues has emerged as an important posttranslational
modification in mammalian cells. Previous studies have suggested a primary role for …
modification in mammalian cells. Previous studies have suggested a primary role for …
Mechanistic Studies on the Bioactivation of Diclofenac: Identification of Diclofenac-S-acyl-glutathione in Vitro in Incubations with Rat and Human Hepatocytes
MP Grillo, F Hua, CG Knutson, JA Ware… - Chemical research in …, 2003 - ACS Publications
Diclofenac, a nonsteroidal anti-inflammatory drug, is metabolized to diclofenac-1-O-acyl
glucuronide (D-1-O-G), a chemically reactive conjugate that has been implicated as playing a …
glucuronide (D-1-O-G), a chemically reactive conjugate that has been implicated as playing a …