Histamine is a multifunctional hormone that regulates smooth muscle contraction in the
airways, acid secretion in the gut, and neurotransmitter release in the central nervous system …

Lactic acid is a well known metabolic by-product of intense exercise, particularly under anaerobic
conditions. Lactate is also a key source of energy and an important metabolic substrate…

The RAR-related orphan receptor gamma t (RORγt) is a nuclear receptor required for generating
IL-17–producing CD4 + Th17 T cells, which are essential in host defense and may play …

We have recently described the cloning and characterization of a novel corticotropin-releasing
factor receptor subtype (CRF2) from rat brain that exists in two alternatively spliced forms, …

Neuropathic pain is a common and often incapacitating clinical problem for which little useful
therapy is presently available. Painful peripheral neuropathies can have many etiologies, …

GPCR135, publicly known as somatostatin- and angiotensin-like peptide receptor, is expressed
in the central nervous system and its cognate ligand(s) has not been identified. We have …

EBI2 (also called GPR183) is an orphan G-protein-coupled receptor that is highly expressed
in spleen and upregulated upon Epstein–Barr-virus infection 1 . Recent studies indicated …

We have recently identified the insulin-like peptide relaxin-3 (aka INSL7) as the endogenous
ligand for an orphan G-protein-coupled receptor, GPCR135 (aka somatostatin- and …

Brain histamine H 3 receptors are predominantly presynaptic and serve an important
autoregulatory function for the release of histamine and other neurotransmitters. They have been …

Relaxin-3 (RLX3) is a newly identified member of the relaxin/insulin peptide family that is
highly conserved across a range of species from fish to mammals and is highly expressed in rat…