Characterization of the analgesic and anti-inflammatory activities of ketorolac and its enantiomers in the rat

MF Jett, CS Ramesha, CD Brown, S Chiu… - … of Pharmacology and …, 1999 - ASPET
… (s) contribute to its analgesic actions. To evaluate this possibility, we characterized (R,S)-ketorolac’s
The potency of racemic (R,S)-ketorolac was similar in tests of acetic acid-induced …

Human and rat cyclooxygenases are pharmacologically distinct

CS Ramesha - Eicosanoids and other Bioactive Lipids in Cancer …, 1997 - Springer
Cyclooxygenase-1 (COX-1), which is constitutively expressed in most tissues and cyclooxygenase-2
(COX-2) which is induced in response to various inflammatory stimuli 1,2 are about …

Discovery of S-[5-Amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an Orally Bioavailable and Highly Selective …

…, F Li, E Papp, D McWeeney, C Ramesha… - Journal of medicinal …, 2006 - ACS Publications
A novel class of highly selective inhibitors of p38 MAP kinase was discovered from high
throughput screening. The synthesis and optimization of a series of 5-amino-N-phenyl-1H-…

Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2

…, A Miller, J Barnett, J Chow, C Ramesha… - Nature structural …, 1996 - nature.com
… of this domain are well conserved; 0.7 Å rm.s. deviation for all backbone atoms. The single
… Comparison of the catalytic core for the open and closed COX-2 structures shows an rm.s. …

Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system

…, C Bach, J Freire, H Chan, E Sigal, C Ramesha - … et Biophysica Acta (BBA …, 1994 - Elsevier
… After 45 s at room temperature, the reaction was terminated by adding 100 /xl of 2 N HC1
and 750 /zl water. An aliquot (950 /zl) of the reaction mixture was loaded onto a 1 ml C18 Sep-…

[HTML][HTML] A four-point screening method for assessing molecular mechanism of action (MMOA) identifies tideglusib as a time-dependent inhibitor of Trypanosoma …

…, BA Haubrich, S Xia, C Ramesha… - PLoS neglected …, 2016 - journals.plos.org
… This change can be theoretically calculated by the following equation derived from the
equation for competitive inhibition, (2) where S 1 and S 2 are the two substrate concentrations; v 1 …

Rational design of 6-methylsulfonylindoles as selective cyclooxygenase-2 inhibitors

…, JM Kress, T Mirzadegan, C Ramesha… - Bioorganic & medicinal …, 2004 - Elsevier
… Against a panel of liver P450 isozymes, the IC 50 s of compound 8a were >15 μM with the
exception of 2C19 (7 μM), while the IC 50 s of compound 14b were >16 μM against all the …

[PDF][PDF] Synthesis and characterization of impurities of an anti-psychotic drug substance, Olanzapine

…, C Bulusu, R Chakka, PR Padi, A Yerra, S Bollikonda - Arkivoc, 2008 - arkat-usa.org
HPLC analysis of olanzapine 1, a known anti-psychotic drug, showed impurity peaks ranging
from 0.05 to 0.15% during process development. These samples were analyzed by LCMS …

Development of a bioluminescent high-throughput screening assay for nicotinamide mononucleotide adenylyltransferase (NMNAT)

BA Haubrich, C Ramesha… - … Advancing Life Sciences …, 2020 - journals.sagepub.com
… Brian S. Blais, Bryant University, for assistance with statistical analyses; and Dr. Peter Gund,
… See the impact this article is making through the number of times it’s been read, and the …

Gallic acid a flavonoid isolated from Euphorbia hirta antagonizes gamma radiation induced radiotoxicity in lymphocytes in vitro

R Chakka, R Vadaguru Dakshinamurthy… - … of Complementary and …, 2023 - degruyter.com
… Graph pad prism5 software was used to analyse the data gathered from the current study
using ANOVA and a post hoc Dunnett’s t-test. To display all of the data, the mean and standard …