Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors

KD Burris, TF Molski, C Xu, E Ryan, K Tottori… - … of Pharmacology and …, 2002 - ASPET
Aripiprazole is the first next-generation atypical antipsychotic with a mechanism of action
that differs from currently marketed typical and atypical antipsychotics. Aripiprazole displays …

Pharmacology and regulation of the neuronal dopamine transporter

MEA Reith, C Xu, NH Chen - European journal of pharmacology, 1997 - Elsevier
The dopamine transporter, a member of the family of Na + ,Cl − -dependent transporters,
mediates uptake of dopamine into dopaminergic neurons by an electrogenic, Na + − and Cl − -…

Therapeutic monoclonal antibodies: what headache specialists need to know

S Silberstein, R Lenz, C Xu - … : The Journal of Head and Face …, 2015 - Wiley Online Library
Background Monoclonal antibodies (mAbs) are now an important part of the treatment
armamentarium for a wide range of conditions including cancer, autoimmune diseases, …

Role of Calcitonin Gene-Related Peptide on the Gastrointestinal Symptoms of Migraine—Clinical Considerations: A Narrative Review

…, AF Russo, C Vélez, AP Ramajo, A Abdrabboh, C Xu… - Neurology, 2022 - AAN Enterprises
Calcitonin gene-related peptide (CGRP) is involved in several of the pathophysiologic processes
underpinning migraine attacks. Therapies that target CGRP or its receptor have shown …

Pharmacologic characterization of AMG 334, a potent and selective human monoclonal antibody against the calcitonin gene-related peptide receptor

…, J Zhang, BP Smith, DC Immke, KD Wild, C Xu - … of Pharmacology and …, 2016 - ASPET
Therapeutic agents that block the calcitonin gene–related peptide (CGRP) signaling pathway
are a highly anticipated and promising new drug class for migraine therapy, especially …

Characterization of a New GlnR Binding Box in the Promoter of amtB in Streptomyces coelicolor Inferred a PhoP/GlnR Competitive Binding Mechanism for Transcriptional …

Y Wang, XF Cen, GP Zhao, J Wang - Journal of bacteriology, 2012 - Am Soc Microbiol
The transcription of amtB in Streptomyces coelicolor has been proposed to be counter-regulated
by GlnR (a global regulator for nitrogen metabolism) and PhoP (a global regulator for …

Synthesis and structure–activity relationship of novel benzoxazole derivatives as melatonin receptor agonists

…, G Johnson, L Iben, CD Mahle, E Ryan, C Xu - Bioorganic & medicinal …, 2004 - Elsevier
A series of benzoxazole derivatives was synthesized and evaluated as melatoninergic
ligands. The binding affinity of these compounds for human MT 1 and MT 2 receptors was …

Immunohistochemical localization of the calcitonin gene-related peptide binding site in the primate trigeminovascular system using functional antagonist antibodies

S Miller, H Liu, K Warfvinge, L Shi, M Dovlatyan, C Xu… - Neuroscience, 2016 - Elsevier
Calcitonin gene-related peptide (CGRP) is a potent vasodilator and a neuromodulator
implicated in the pathophysiology of migraine. It binds to the extracellular domains of calcitonin …

Design and synthesis of benzoxazole derivatives as novel melatoninergic ligands

…, G Johnson, L Iben, CD Mahle, E Ryan, C Xu - Bioorganic & medicinal …, 2004 - Elsevier
A novel series of benzoxazole derivatives was synthesized and evaluated as melatoninergic
ligands. The binding affinity of these compounds for human MT 1 and MT 2 receptors was …

[HTML][HTML] Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism

…, Y Ding, R Ren, EH Harrington, LA Hu, W Zhong, C Xu… - Cell research, 2020 - nature.com
The pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1R) belongs to
the secretin receptor family and is widely distributed in the central neural system and …