The conventional pipeline for biomarker development involves a discovery phase, typically
conducted by mass spectrometry (MS), followed by validation and clinical application, usually …

Covalent binding to proteins to form neoantigens is thought to be central to the pathogenesis
of penicillin hypersensitivity reactions. We have undertaken detailed mass spectrometric …

Rising population density and global mobility are among the reasons why pathogens such
as SARS-CoV-2, the virus that causes COVID-19, spread so rapidly across the globe. The …

Hypothesis‐driven MS‐based targeted proteomics has gained great popularity in a relatively
short timespan. Next to the widely established selected reaction monitoring (SRM) workflow…

… The authors declare the following competing financial interest(s): Catherine S. Lane and J.
Larry Campbell are employed by AB SCIEX, which sells the differential mobility spectrometry …

Background Global healthcare systems continue to be challenged by the COVID-19 pandemic,
and there is a need for clinical assays that can help optimise resource allocation, support …

Differential mobility spectrometry (DMS) has been employed to separate isomeric species in
several studies. Under the right conditions, factors such as separation voltage, temperature, …

Blood is recognised as a highly important source of disease-related biomarkers, and proteomic
approaches for identifying novel blood-borne biomarkers are in demand. The complexity …

Celiac disease (CD) is a disease of the small intestine that occurs in genetically susceptible
subjects triggered by the ingestion of cereal gluten proteins for which the only treatment is …

Chemically reactive metabolites (CRMs) are thought to be responsible for a number of
adverse drug reactions through modification of critical proteins. Methods that defined the …