Multiple reaction monitoring for quantitative biomarker analysis in proteomics and metabolomics
NR Kitteringham, RE Jenkins, CS Lane… - … of Chromatography B, 2009 - Elsevier
The conventional pipeline for biomarker development involves a discovery phase, typically
conducted by mass spectrometry (MS), followed by validation and clinical application, usually …
conducted by mass spectrometry (MS), followed by validation and clinical application, usually …
Direct evidence for the formation of diastereoisomeric benzylpenicilloyl haptens from benzylpenicillin and benzylpenicillenic acid in patients
…, NG Berry, JL Maggs, J Farrell, CS Lane… - … of Pharmacology and …, 2011 - ASPET
Covalent binding to proteins to form neoantigens is thought to be central to the pathogenesis
of penicillin hypersensitivity reactions. We have undertaken detailed mass spectrometric …
of penicillin hypersensitivity reactions. We have undertaken detailed mass spectrometric …
Cov-MS: a community-based template assay for mass-spectrometry-based protein detection in SARS-CoV-2 patients
Rising population density and global mobility are among the reasons why pathogens such
as SARS-CoV-2, the virus that causes COVID-19, spread so rapidly across the globe. The …
as SARS-CoV-2, the virus that causes COVID-19, spread so rapidly across the globe. The …
Assessment of SRM, MRM3, and DIA for the targeted analysis of phosphorylation dynamics in non‐small cell lung cancer
…, L Garrigues, CS Lane, TC Mulder, S van Doorn… - …, 2016 - Wiley Online Library
Hypothesis‐driven MS‐based targeted proteomics has gained great popularity in a relatively
short timespan. Next to the widely established selected reaction monitoring (SRM) workflow…
short timespan. Next to the widely established selected reaction monitoring (SRM) workflow…
Separation of sialylated glycan isomers by differential mobility spectrometry
CS Lane, K McManus, P Widdowson… - Analytical …, 2019 - ACS Publications
… The authors declare the following competing financial interest(s): Catherine S. Lane and J.
Larry Campbell are employed by AB SCIEX, which sells the differential mobility spectrometry …
Larry Campbell are employed by AB SCIEX, which sells the differential mobility spectrometry …
[HTML][HTML] A multiplex protein panel assay for severity prediction and outcome prognosis in patients with COVID-19: an observational multi-cohort study
…, S Hippenstiel, LE Sander, D Blake, CS Lane… - …, 2022 - thelancet.com
Background Global healthcare systems continue to be challenged by the COVID-19 pandemic,
and there is a need for clinical assays that can help optimise resource allocation, support …
and there is a need for clinical assays that can help optimise resource allocation, support …
Analyzing glycopeptide isomers by combining differential mobility spectrometry with electron-and collision-based tandem mass spectrometry
Differential mobility spectrometry (DMS) has been employed to separate isomeric species in
several studies. Under the right conditions, factors such as separation voltage, temperature, …
several studies. Under the right conditions, factors such as separation voltage, temperature, …
A technically detailed and pragmatic protocol for quantitative serum proteomics using iTRAQ
…, RE Jenkins, V Elliot, S Murray, CS Lane… - Journal of …, 2009 - Elsevier
Blood is recognised as a highly important source of disease-related biomarkers, and proteomic
approaches for identifying novel blood-borne biomarkers are in demand. The complexity …
approaches for identifying novel blood-borne biomarkers are in demand. The complexity …
Comparing multiple reaction monitoring and sequential window acquisition of all theoretical mass spectra for the relative quantification of barley gluten in selectively …
…, M Blundell, S Heidelberger, CS Lane… - Analytical …, 2016 - ACS Publications
Celiac disease (CD) is a disease of the small intestine that occurs in genetically susceptible
subjects triggered by the ingestion of cereal gluten proteins for which the only treatment is …
subjects triggered by the ingestion of cereal gluten proteins for which the only treatment is …
Glutathione‐S‐transferase pi as a model protein for the characterisation of chemically reactive metabolites
…, CEP Goldring, SMJ Dowdall, J Hamlett, CS Lane… - …, 2008 - Wiley Online Library
Chemically reactive metabolites (CRMs) are thought to be responsible for a number of
adverse drug reactions through modification of critical proteins. Methods that defined the …
adverse drug reactions through modification of critical proteins. Methods that defined the …