One of the first hallmarks of kidney regeneration is the reactivation of genes normally
required during organogenesis. Identification of chemicals with the potential to enhance this …

Disorazoles comprise a family of 29 macrocyclic polyketides isolated from the fermentation
broth of the myxobacterium Sorangium cellulosum. The major fermentation product, …

A major challenge for the treatment of cancers, such as glioblastoma multiforme (GBM), has
been resistance to radiation and cancer chemotherapeutics. Short interfering RNA (siRNA) …

Coordinated microtubule polymerization and depolymerization is essential for numerous
biological functions, including mitotic spindle formation, making microtubules a prime target for …

Discovering chemosensitivity pathways or nodes is an attractive strategy for formulating new
drug combinations for cancer. Microtubules are among the most successful anticancer drug …

Disorazoles are macrocyclic polyketides first isolated from the fermentation broth of the
myxobacterium Sorangium cellulosum. Both the major fermentation product disorazole A 1 and …

Self-assembled monolayers (SAMs) of glucose derivatives on gold have been prepared
from α- and β-glucopyranosylamide derivatives. The glucosyl conjugates were synthesized …

The majority of current pharmacological treatments for cancer target rapidly dividing cells, a
characteristic of most cancer cells. Unfortunately, these treatments also affect cells that …

To identify novel chemosensitivity nodes for vinblastine, a clinically used microtubule destabilizing
agent, we implemented a short interfering RNA synthetic lethal screen targeting 5,520 …

Cellular senescence is a permanent state of cell cycle arrest that prevents cell proliferation
but allows the cells to be metabolically active. Premature cellular senescence is stimulated by …