High affinity radiopharmaceuticals based upon lansoprazole for PET imaging of aggregated tau in Alzheimer's disease and progressive supranuclear palsy: synthesis …

…, TJ Desmond, P Sherman, CA Quesada… - ACS chemical …, 2014 - ACS Publications
Abnormally aggregated tau is the hallmark pathology of tauopathy neurodegenerative
disorders and is a target for development of both diagnostic tools and therapeutic strategies …

125I-Labeled Gold Nanorods for Targeted Imaging of Inflammation

…, DL Chamberland, PS Sherman, CA Quesada… - ACS …, 2011 - ACS Publications
For better examination of inflammation, we designed inflammation-targeted nuclear and
optical dual-modality contrast agents prepared by I-125 radiolabeling of gold nanorods (GdNRs) …

Synthesis of Diverse 11C-Labeled PET Radiotracers via Direct Incorporation of [11C]CO2

…, AF Brooks, IM Jackson, CA Quesada… - Bioconjugate …, 2016 - ACS Publications
Three new positron emission tomography (PET) radiotracers of interest to our functional
neuroimaging and translational oncology programs have been prepared through new …

Evaluation of [11C]N-Methyl Lansoprazole as a Radiopharmaceutical for PET Imaging of Tau Neurofibrillary Tangles

…, TJ Desmond, P Sherman, CA Quesada… - ACS medicinal …, 2012 - ACS Publications
[ 11 C]N-Methyl lansoprazole ([ 11 C]NML, 3) was synthesized and evaluated as a
radiopharmaceutical for quantifying tau neurofibrillary tangle (NFT) burden using positron emission …

Synthesis and Evaluation of [18F]RAGER: A First Generation Small-Molecule PET Radioligand Targeting the Receptor for Advanced Glycation Endproducts

…, TJ Desmond, P Sherman, CA Quesada… - ACS chemical …, 2016 - ACS Publications
The receptor for advanced glycation endproducts (RAGE) is a 35 kDa transmembrane
receptor that belongs to the immunoglobulin superfamily of cell surface molecules. Its role in …

Synthesis and Initial in Vivo Studies with [11C]SB-216763: The First Radiolabeled Brain Penetrative Inhibitor of GSK-3

…, DJ Williamson, TD Fryer, CA Quesada… - ACS Medicinal …, 2015 - ACS Publications
Quantifying glycogen synthase kinase-3 (GSK-3) activity in vivo using positron emission
tomography (PET) imaging is of interest because dysregulation of GSK-3 is implicated in …

4-[18F]Fluoro-m-hydroxyphenethylguanidine: A Radiopharmaceutical for Quantifying Regional Cardiac Sympathetic Nerve Density with Positron Emission …

…, RA Koeppe, PS Sherman, CA Quesada… - Journal of medicinal …, 2013 - ACS Publications
4-[ 18 F]Fluoro-m-hydroxyphenethylguanidine ([ 18 F]4F-MHPG, [ 18 F]1) is a new cardiac
sympathetic nerve radiotracer with kinetic properties favorable for quantifying regional nerve …

Intranasal opioid administration in rhesus monkeys: PET imaging and antinociception

…, KA Zelenock, X Shao, P Sherman, CA Quesada… - … of Pharmacology and …, 2016 - ASPET
The goal of this study was to evaluate the effects of intranasally administered opioids in rhesus
monkeys using the tail-withdrawal assay, and to correlate these effects with measures of …

A kinome-wide selective radiolabeled TrkB/C inhibitor for in vitro and in vivo neuroimaging: synthesis, preclinical evaluation, and first-in-human

…, A Aliaga, X Shao, CA Quesada… - Journal of Medicinal …, 2017 - ACS Publications
The proto-oncogenes NTRK1/2/3 encode the tropomyosin receptor kinases TrkA/B/C which
play pivotal roles in neurobiology and cancer. We describe herein the discovery of [ 11 C]-(R)…

Imaging of carrageenan-induced local inflammation and adjuvant-induced systemic arthritis with [11C] PBR28 PET

…, T Desmond, PS Sherman, CA Quesada… - Nuclear medicine and …, 2013 - Elsevier
Introduction [ 11 C] PBR28 binding to translocator protein (TSPO) was evaluated for imaging
of acute and chronic inflammation using two established rat models. Methods Acute …