One of the most intriguing examples of cross talk between signaling systems is the interrelationship
between G protein-coupled receptor and growth factor receptor pathways leading to …

Acute μ and κ opioids activate the ERK/MAPK phosphorylation cascade that represents an
integral part of the signaling pathway of growth factors in astrocytes. By this cross-talk, opioids …

Previous data indicated that opioid receptors occur in both neural and nonneural human
tumors. However, it has recently been shown that some of the putative opioid binding may be …

We investigated the postnatal ontogeny of opioid receptors in rat brain under assay conditions
which, when combined with computerized analysis, effectively reflect the developmental …

Phosphorylation of the MAPK isoform ERK by G protein-coupled receptors involves multiple
signaling pathways. One of these pathways entails growth factor receptor transactivation …

Although it is well‐established that G protein‐coupled receptor signaling systems can
network with those of tyrosine kinase receptors by several mechanisms, the point(s) of …

GTP binding regulatory protein (G protein)‐coupled receptors can activate MAPK pathways
via G protein‐dependent and ‐independent mechanisms. However, the physiological …

As reports on G protein‐coupled receptor signal transduction mechanisms continue to
emphasize potential differences in signaling due to relative receptor levels and cell type …

Growth factors, hormones, and neurotransmitters have been implicated in the regulation of
stem cell fate. Since various neural precursors express functional neurotransmitter receptors, …

Previously, we implicated the opioid receptor (OR), G βγ subunits, and Ras in the opioid
activation of extracellular signal-regulated protein kinase (ERK), a member of the mitogen-…