The antihistaminic-antiserotonin actions of 1-methyl-4-(5 -dibenzo[a,e]
cycloheptatrienylidine)-piperidine hydrochloride (cyproheptadine) have been demonstrated in …

A series of compounds related to cyproheptadine hasbeen prepared and the antihistaminic
and antiserotonin properties were studied. The structural variations include: replacement of …

The antidepressant drugs, protriptyline, imipramine, amitriptyline and their desmethyl derivatives,
have been demonstrated to be capable of inhibiting catecholamine depletion in hearts …

6-Hydroxydopamine, 6-aminodopamine and α-methyl-6-hydroxydopamine were demonstrated
to possess certain pharmacologic actions characteristic of reserpine and guanethidine. …

The long-term survival of rats with healed myocardial infarction and congestive heart failure
treated with milrinone, enalapril and the combination of milrinone plus enalapril, was …

Methyldopa (α-methyl-3,4-dihydroxyphenyl-alanine), α-methyl-meta-tyrosine and their respective
α-methyl-dihydroxyphenethylamines were demonstrated to be capable of antagonizing …

St-91, 2(2,6-diethylphenylamino)-2-imidazoline ∗∗ , is a clonidine derivative which does
not penetrate the blood-brain barrier. In spontaneously hypertensive (SH) rats is acutely …

The hemodynamic and renal electrolyte/function effects of a synthetic peptide (ANF)
corresponding to the sequence of the 26 amino acids contained in atrial natriuretic factor (ANF) …

Conclusions 1. Atropine and morphine effectively block angiotensin and nicotine-induced
spasm on the isolated guinea pig ileum. 2. Mecamylamine, pempidine, pentolinium and …

Two methods for arriving at optimum, individual phenytoin dosage regimens have been
evaluated in 12 patients. (1) Individual Michaelis‐Menten pharmacokinetic parameters for …