High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability

…, D Goodale, J Chu, C Postenka… - Journal of cellular …, 2009 - Wiley Online Library
Cancer stem cells (CSCs) have recently been identified in leukaemia and solid tumours;
however, the role of CSCs in metastasis remains poorly understood. This dearth of knowledge …

[HTML][HTML] Invadopodia are required for cancer cell extravasation and are a therapeutic target for metastasis

…, K Carmine-Simmen, VA McPherson, CO Postenka… - Cell reports, 2014 - cell.com
Tumor cell extravasation is a key step during cancer metastasis, yet the precise mechanisms
that regulate this dynamic process are unclear. We utilized a high-resolution time-lapse …

Role of the integrin-binding protein osteopontin in lymphatic metastasis of breast cancer

…, RL Holliday, DP Girvan, LA Scott, CO Postenka… - The American journal of …, 2006 - Elsevier
Although a primary route of breast cancer metastasis is believed to be via lymphatics, the
molecular factors involved are poorly understood. We hypothesized that one such factor may …

β3 Integrin Expression Increases Breast Carcinoma Cell Responsiveness to the Malignancy-Enhancing Effects of Osteopontin

…, SM Wilson, C Hota, SA Vantyghem, CO Postenka… - Molecular cancer …, 2003 - AACR
Osteopontin (OPN) is a secreted phosphoprotein that has been associated with malignancy
of breast and other cancers. OPN binds to several cell surface integrins including α v β 3 , α …

Dietary genistein reduces metastasis in a postsurgical orthotopic breast cancer model

SA Vantyghem, SM Wilson, CO Postenka, W Al-Katib… - Cancer Research, 2005 - AACR
Metastatic spread, not primary tumor burden, is the leading cause of breast cancer deaths.
For patient prognosis to improve, new systemic adjuvant therapies that are capable of …

Three-dimensional high-frequency ultrasound imaging for longitudinal evaluation of liver metastases in preclinical models

KC Graham, LA Wirtzfeld, LT MacKenzie, CO Postenka… - Cancer Research, 2005 - AACR
Liver metastasis is a clinically significant contributor to the mortality associated with melanoma,
colon, and breast cancer. Preclinical mouse models are essential to the study of liver …

[HTML][HTML] Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis

B Goulet, W Kennette, A Ablack, CO Postenka… - Laboratory …, 2011 - Elsevier
Maspin (mammary serine protease inhibitor or SerpinB5) acts as a tumor suppressor when
overexpressed in aggressive cancer cell lines. However, its role in human cancer is …

TBX3 promotes progression of pre‐invasive breast cancer cells by inducing EMT and directly up‐regulating SLUG

…, MJ Cecchini, CO Postenka… - The Journal of …, 2019 - Wiley Online Library
The acquisition of cellular invasiveness by breast epithelial cells and subsequent transition
from ductal carcinoma in situ (DCIS) to invasive breast cancer is a critical step in breast …

The thrombin inhibitor Argatroban reduces breast cancer malignancy and metastasis via osteopontin-dependent and osteopontin-independent mechanisms

…, BD Hedley, D Goodale, CO Postenka… - Breast cancer research …, 2008 - Springer
Osteopontin (OPN) has been clinically and experimentally associated with breast cancer
metastasis. Proteolytic cleavage of OPN by thrombin has been reported to increase its biologic …

[HTML][HTML] EMT-independent detection of circulating tumor cells in human blood samples and pre-clinical mouse models of metastasis

J Kitz, D Goodale, C Postenka, LE Lowes… - Clinical & Experimental …, 2021 - Springer
Circulating tumor cells (CTCs) present an opportunity to detect/monitor metastasis throughout
disease progression. The CellSearch® is currently the only FDA-approved technology for …