Buprenorphine is a mixed opioid receptor agonist-antagonist used clinically for maintenance
therapy in opiate addicts and pain management. Dose-response curves for buprenorphine-…

Separate breeding colonies of C57BL/6 (“B6”) mice maintained at the Jackson Laboratories
(“J”) and NIH (“N”) have led to the emergence of two distinct substrains of C57BL/6 mice: …

Emerging studies suggest a role for tau in regulating the biology of RNA binding proteins (RBPs).
We now show that reducing the RBP T-cell intracellular antigen 1 (TIA1) in vivo …

Eating disorders (anorexia nervosa, bulimia nervosa and binge-eating disorder) are a
heterogeneous class of complex illnesses marked by weight and appetite dysregulation coupled …

… Camron D. Bryant … Behavioral differences between B6/J and B6/N in ethanol consumption
and preference were noted in the early 1980s and have since been replicated in at least two …

Background Eating disorders are lethal and heritable; however, the underlying genetic factors
are unknown. Binge eating is a highly heritable trait associated with eating disorders that …

Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit
maps are increasingly available, knowledge of their underlying molecular networks remains …

We tested the role of sex chromosome complement and gonadal hormones in sex differences
in several different paradigms measuring nociception and opioid analgesia using “four …

Transcriptional and post‐transcriptional regulation of gene expression defines the neurobiological
mechanisms that bridge genetic and environmental risk factors with neurobehavioral …

Opioid-receptor activation in cell lines results in phosphorylation of p42/44 mitogen-activated
protein kinase (MAPK), which contributes to agonist-induced desensitization of adenylate …