Nonribosomal peptide synthetases are large enzyme complexes that synthesize a variety of
peptide natural products through a thiotemplated mechanism. Assembly of the peptides …

Ubiquitination controls the stability of most cellular proteins, and its deregulation contributes
to human diseases including cancer. Deubiquitinases remove ubiquitin from proteins, and …

Nonribosomal peptide synthetases (NRPSs) are large, multidomain enzymes that
biosynthesize medically important natural products. We report the crystal structure of the free-standing …

Amplification of the CCNE1 locus on chromosome 19q12 is prevalent in multiple tumour
types, particularly in high-grade serous ovarian cancer, uterine tumours and gastro-…

The glycopeptide antibiotics vancomycin and teicoplanin are vital components of modern
anti-infective chemotherapy exhibiting outstanding activity against Gram-positive pathogens …

Vibriobactin [N 1 -(2,3-dihydroxybenzoyl)-N 5 ,N 9 -bis[2-(2,3-dihydroxyphenyl)-5-methyloxazolinyl-4-carboxamido]norspermidine],
is an iron chelator from the cholera-causing …

KIF14 is a microtubule motor protein whose elevated expression is associated with poor-prognosis
breast cancer. Here we demonstrate KIF14 accumulation in mitotic cells, where it …

A large number of therapeutically useful natural peptides are produced nonribosomally by
assembly line enzymology, involving multidomain and multimodular catalysts that activate …

The Vibrio cholerae siderophore vibriobactin is biosynthesized from three molecules of 2,3-dihydroxybenzoate
(DHB), two molecules of l-threonine, and one of norspermidine. Of the …

The iron-chelating catechol siderophore vibriobactin of the pathogenic Vibrio cholerae is
assembled by a four-subunit, ten-domain nonribosomal peptide synthetase system, VibE, VibB, …