Quantitation of urinary metabolites of a tobacco-specific lung carcinogen after smoking cessation

…, AT Miller, SE Murphy, JA Jensen, CL Zimmerman… - Cancer research, 1999 - AACR
… It was mixed with 1 ml of 50% aqueous K 2 CO 3 and then extracted once with 2 ml of CH
2 Cl 2 . The CH 2 Cl 2 layer was separated and mixed with 200 μl of CH 3 OH. This solution …

Rapid analysis of amino acid phenylthiohydantoins by high-performance liquid chromatography

CL Zimmerman, E Appella, JJ Pisano - Analytical biochemistry, 1977 - Elsevier
All 20 amino acid phenylthiohydantoins (PTHs) can be separated in a single analysis in less
than 20 min using a 25 × 0.46-cm DuPont Zorbax ODS column developed with a gradient of …

Chemoprevention of pulmonary carcinogenesis by brief exposures to aerosolized budesonide or beclomethasone dipropionate and by the combination of aerosolized …

…, TS Wiedmann, RD Estensen, CL Zimmerman… - …, 2000 - academic.oup.com
This investigation is part of an effort to develop chemoprevention for carcinogenesis of the
lung. It focuses on the efficacy of low doses of synthetic glucocorticoids administered either as …

Effects of reduced cigarette smoking on the uptake of a tobacco-specific lung carcinogen

…, SG Carmella, CL Zimmerman… - Journal of the …, 2004 - academic.oup.com
Background: Limited data are available on carcinogen uptake in smokers who reduce their
smoking. To determine whether reducing the number of cigarettes smoked per day would …

Chemoprevention of pulmonary carcinogenesis by aerosolized budesonide in female A/J mice

…, TS Wiedmann, RD Estensen, CL Zimmerman… - Cancer research, 1997 - AACR
This investigation is part of a continuing effort to develop effective chemoprevention for
carcinogenesis of the lung. The present study explores the use of aerosol administrations for this …

Planning for restoration: a decision analysis approach to prioritization

…, AL Maruyama, CL Zimmerman - Restoration Ecology, 2005 - Wiley Online Library
Ecological restoration often relies on the use of expert opinion to make management decisions
in the face of uncertainty. The quantification of expert opinion can be difficult, especially …

Quantitation of metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone after cessation of smokeless tobacco use

…, SG Carmella, M Ye, K Le, JA Jensen, CL Zimmerman… - Cancer research, 2002 - AACR
Two major metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
(NNK) were previously shown to be highly persistent in human urine after …

An integrated PK‐PD model for cortisol and the 17‐hydroxyprogesterone and androstenedione biomarkers in children with congenital adrenal hyperplasia

…, TN Tran, BA Willis, CL Zimmerman… - British Journal of …, 2021 - Wiley Online Library
Aims The aim of this study was to characterize the pharmacokinetic/pharmacodynamic
relationships of cortisol and the adrenal biomarkers 17‐hydroxyprogesterone and …

Interrelationships among cortisol, 17-hydroxyprogesterone, and androstenendione exposures in the management of children with congenital adrenal hyperplasia

K Sarafoglou, CL Zimmerman… - Journal of …, 2015 - journals.sagepub.com
… ; we would have expected our value of CL/F to be higher because the bioavailability of
oral hydrocortisone is less than 100% (94.2%). Also affecting clearance, our subjects were …

Comparison of cortisol exposures and pharmacodynamic adrenal steroid responses to hydrocortisone suspension vs. commercial tablets

…, MT Gonzalez‐Bolanos, CL Zimmerman… - The Journal of …, 2015 - Wiley Online Library
The Endocrine Society Clinical Practice Guidelines on congenital adrenal hyperplasia (CAH)
recommend against using hydrocortisone suspension based on a study that examined a …