Focalized proteolysis: spatial and temporal regulation of extracellular matrix degradation at the cell surface

CB Basbaum, Z Werb - Current opinion in cell biology, 1996 - Elsevier
… temporal regulation of extracellular matrix degradation at the cell surface Carol B Basbaum*
… of extracellular matrix degradation at the cell surface Carol B Basbaum* and Zena Werb …

The serous cell

CB Basbaum, B Jany… - Annual Review of …, 1990 - annualreviews.org
Basbaum, unpublished observations) as well as in the tracheal lumen and epithelial …
Basbaum, unpublished data). In view of the almost inevitable loss of function because of …

Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells.

…, JA Nadel, CB Basbaum… - The Journal of …, 1990 - Am Soc Clin Investig
To investigate the hypothesis that neutrophil proteases stimulate airway gland secretion, we
studied the effect of human cathepsin G and elastase on secretion of 35S-labeled …

Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease

…, JA Nadel, A Prince, CB Basbaum - Proceedings of the …, 1997 - National Acad Sciences
An unresolved question in cystic fibrosis (CF) research is how mutations of the CF transmembrane
conductance regulator, a Cl ion channel, cause airway mucus obstruction leading to …

Localization of mucin (MUC2 and MUC3) messenger RNA and peptide expression in human normal intestine and colon cancer

SK Chang, AF Dohrman, CB Basbaum, SB Ho, T Tsuda… - Gastroenterology, 1994 - Elsevier
Basbaum CB, Finkbeiner WE. Mucus-producing cells of the airways. In: Massaro D, ed. …
Basbaum CB. Human bronchus and intestine express the same mucin gene. J Clin Invest 1991;…

Characterization of human tracheal epithelial cells transformed by an origin-defective simian virus 40.

DC Gruenert, CB Basbaum, MJ Welsh… - Proceedings of the …, 1988 - National Acad Sciences
To facilitate understanding of the mechanisms underlying pulmonary diseases, including
lung cancer and cystic fibrosis, we have transformed and characterized cultures of human …

[HTML][HTML] Cloning of the amino-terminal and 5′-flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts

…, N Fan, DE Szymkowski, CB Basbaum - Journal of Biological …, 1998 - ASBMB
To obtain gene regulatory sequence for the mucin gene MUC5AC, we have isolated the
MUC5AC amino terminus cDNA and 5′-flanking region. This was possible through the use of …

Nontypeable Haemophilus influenzae lipoprotein P6 induces MUC5AC mucin transcription via TLR2–TAK1-dependent p38 MAPK-AP1 and IKKβ-IκBα-NF-κB …

…, JH Lim, H Jono, XX Gu, YS Kim, CB Basbaum… - Biochemical and …, 2004 - Elsevier
Mucin overproduction is a hallmark of nontypeable Haemophilus influenzae (NTHi)
infections. The molecular mechanisms underlying up-regulation of mucin in NTHi infections …

[HTML][HTML] Phorbol 12-Myristate 13-Acetate Up-regulates the Transcription of MUC2Intestinal Mucin via Ras, ERK, and NF-κB

…, SC Crawley, JD Li, JR Gum, CB Basbaum… - Journal of Biological …, 2002 - ASBMB
MUC2 is a secretory mucin normally expressed by goblet cells of the intestinal epithelium. It
is overexpressed in mucinous type colorectal cancers but down-regulated in colorectal …

[HTML][HTML] Novel cytoplasmic proteins of nontypeable Haemophilus influenzae up-regulate human MUC5AC mucin transcription via a positive p38 mitogen-activated …

B Wang, DJ Lim, J Han, YS Kim, CB Basbaum… - Journal of Biological …, 2002 - ASBMB
Nontypeable Haemophilus influenzae(NTHi) is an important human pathogen that causes
chronic otitis media with effusion (COME) in children and exacerbation of chronic obstructive …