Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation

HJ Zhu, X Wang, BE Gawronski, BJ Brinda… - … of Pharmacology and …, 2013 - ASPET
Clopidogrel pharmacotherapy is associated with substantial interindividual variability in clinical
response, which can translate into an increased risk of adverse outcomes. Clopidogrel, a …

G protein receptor kinase 4 polymorphisms: β-blocker pharmacogenetics and treatment-related outcomes in hypertension

AG Vandell, MT Lobmeyer, BE Gawronski… - …, 2012 - Am Heart Assoc
G protein–coupled receptor kinases (GRKs) are important regulatory proteins for many G
protein–coupled receptors, but little is known about GRK4 pharmacogenetics. We …

[HTML][HTML] Exploring perceptions, knowledge, and attitudes regarding pharmacogenetic testing in the medically underserved

BE Gawronski, EJ Cicali, CW McDonough… - Frontiers in …, 2023 - frontiersin.org
Introduction: Pharmacogenetic testing may hold promise in addressing health disparities, as
medically underserved patients appear to be prescribed medications with pharmacogenetic …

[HTML][HTML] Floppy mitral valve/mitral valve prolapse syndrome: Beta-adrenergic receptor polymorphism may contribute to the pathogenesis of symptoms

…, KD Boudoulas, BE Gawronski… - Journal of …, 2015 - Elsevier
Background Certain patients with floppy mitral valve (FMV)/mitral valve prolapse (MVP) may
have symptoms that cannot be explained on the severity of mitral valvular regurgitation (…

[HTML][HTML] Estimating preferences and willingness to pay for pharmacogenetic testing in populations who are medically underserved: a discrete choice experiment

BE Gawronski, RG Salloum, JD Duarte - Frontiers in Pharmacology, 2024 - frontiersin.org
Background: The implementation of pharmacogenetic (PGx) testing may contribute to health
disparities if access to testing is inequitable, as medically underserved patients are …

CYP2C9 promoter variable number tandem repeat polymorphism regulates mRNA expression in human livers

D Wang, X Sun, Y Gong, BE Gawronski… - Drug Metabolism and …, 2012 - ASPET
CYP2C9 is involved in metabolism of nearly 25% of clinically used drugs. Coding region
polymorphisms CYP2C9*2 and *3 contribute to interperson variability in drug dosage and …

[HTML][HTML] Beta-adrenergic receptor polymorphisms: A basis for pharmacogenetics

…, KD Boudoulas, BE Gawronski… - World Journal of …, 2013 - scirp.org
Aims: Polymorphisms of the β-adrenergic receptor, the frequency of which may differ in ethnic
groups, alters β-receptor function. The aim of this study was to elucidate the frequency of …

[HTML][HTML] Characteristics associated with success for opioid use disorder treatment in court-involved patients

…, BM Bryant, C Cenczyk, B Gawronski - Archives of Clinical and …, 2020 - fortuneonline.org
Objectives: While the Food and Drug Administration (FDA) have approved medications for
opioid use disorder (MOUD), they are underutilized with patients despite established …

[HTML][HTML] High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism

JE Griffin, JD Gawronski, MA DeJesus… - PLoS …, 2011 - journals.plos.org
The pathways that comprise cellular metabolism are highly interconnected, and alterations
in individual enzymes can have far-reaching effects. As a result, global profiling methods that …

Copper efflux system required in murine lung infection by Haemophilus influenzae composed of a canonical ATPase gene and Tandem chaperone gene copies

SM Wong, J Gawronski, BJ Akerley - Infection and Immunity, 2023 - Am Soc Microbiol
Copper is an essential micronutrient but is toxic at high concentrations. In Haemophilus
influenzae mechanisms of copper resistance and its role in pathogenesis are unknown; however…