Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation
Clopidogrel pharmacotherapy is associated with substantial interindividual variability in clinical
response, which can translate into an increased risk of adverse outcomes. Clopidogrel, a …
response, which can translate into an increased risk of adverse outcomes. Clopidogrel, a …
G protein receptor kinase 4 polymorphisms: β-blocker pharmacogenetics and treatment-related outcomes in hypertension
AG Vandell, MT Lobmeyer, BE Gawronski… - …, 2012 - Am Heart Assoc
G protein–coupled receptor kinases (GRKs) are important regulatory proteins for many G
protein–coupled receptors, but little is known about GRK4 pharmacogenetics. We …
protein–coupled receptors, but little is known about GRK4 pharmacogenetics. We …
[HTML][HTML] Exploring perceptions, knowledge, and attitudes regarding pharmacogenetic testing in the medically underserved
BE Gawronski, EJ Cicali, CW McDonough… - Frontiers in …, 2023 - frontiersin.org
Introduction: Pharmacogenetic testing may hold promise in addressing health disparities, as
medically underserved patients appear to be prescribed medications with pharmacogenetic …
medically underserved patients appear to be prescribed medications with pharmacogenetic …
[HTML][HTML] Floppy mitral valve/mitral valve prolapse syndrome: Beta-adrenergic receptor polymorphism may contribute to the pathogenesis of symptoms
…, KD Boudoulas, BE Gawronski… - Journal of …, 2015 - Elsevier
Background Certain patients with floppy mitral valve (FMV)/mitral valve prolapse (MVP) may
have symptoms that cannot be explained on the severity of mitral valvular regurgitation (…
have symptoms that cannot be explained on the severity of mitral valvular regurgitation (…
[HTML][HTML] Estimating preferences and willingness to pay for pharmacogenetic testing in populations who are medically underserved: a discrete choice experiment
BE Gawronski, RG Salloum, JD Duarte - Frontiers in Pharmacology, 2024 - frontiersin.org
Background: The implementation of pharmacogenetic (PGx) testing may contribute to health
disparities if access to testing is inequitable, as medically underserved patients are …
disparities if access to testing is inequitable, as medically underserved patients are …
CYP2C9 promoter variable number tandem repeat polymorphism regulates mRNA expression in human livers
CYP2C9 is involved in metabolism of nearly 25% of clinically used drugs. Coding region
polymorphisms CYP2C9*2 and *3 contribute to interperson variability in drug dosage and …
polymorphisms CYP2C9*2 and *3 contribute to interperson variability in drug dosage and …
[HTML][HTML] Beta-adrenergic receptor polymorphisms: A basis for pharmacogenetics
…, KD Boudoulas, BE Gawronski… - World Journal of …, 2013 - scirp.org
Aims: Polymorphisms of the β-adrenergic receptor, the frequency of which may differ in ethnic
groups, alters β-receptor function. The aim of this study was to elucidate the frequency of …
groups, alters β-receptor function. The aim of this study was to elucidate the frequency of …
[HTML][HTML] Characteristics associated with success for opioid use disorder treatment in court-involved patients
…, BM Bryant, C Cenczyk, B Gawronski - Archives of Clinical and …, 2020 - fortuneonline.org
Objectives: While the Food and Drug Administration (FDA) have approved medications for
opioid use disorder (MOUD), they are underutilized with patients despite established …
opioid use disorder (MOUD), they are underutilized with patients despite established …
[HTML][HTML] High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism
JE Griffin, JD Gawronski, MA DeJesus… - PLoS …, 2011 - journals.plos.org
The pathways that comprise cellular metabolism are highly interconnected, and alterations
in individual enzymes can have far-reaching effects. As a result, global profiling methods that …
in individual enzymes can have far-reaching effects. As a result, global profiling methods that …
Copper efflux system required in murine lung infection by Haemophilus influenzae composed of a canonical ATPase gene and Tandem chaperone gene copies
SM Wong, J Gawronski, BJ Akerley - Infection and Immunity, 2023 - Am Soc Microbiol
Copper is an essential micronutrient but is toxic at high concentrations. In Haemophilus
influenzae mechanisms of copper resistance and its role in pathogenesis are unknown; however…
influenzae mechanisms of copper resistance and its role in pathogenesis are unknown; however…